Self-Aligning Nanojunctions for Integrated Single-Molecule Circuits
Self-Aligning Nanojunctions for Integrated Single-Molecule Circuits
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DOI：
10.1021/acsnano.3c10844
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发表时间：
2024-01-12
期刊：
影响因子：
17.1
通讯作者：
Hihath，Joshua
中科院分区：
文献类型：
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作者：
Liu，Bo;Demir，Busra;Hihath，Joshua
纳米级组件（如石墨烯纳米带、纳米颗粒或单分子）与传统电子电路的稳健、高产率集成已被证明是具有挑战性的。之所以出现这种困难，是因为这些纳米级器件的触点必须以埃级分辨率精确制造，以进行可靠的连接，并且在制造规模下，即使使用最高分辨率的光刻工具也无法实现这一点。在这里，我们介绍了一种方法，通过使用自对准的溶液相工艺在金属碳电极之间精确地产生纳米级的间隙来规避这个问题，该方法可以轻松地与传统的电子系统集成，产率接近50%。通过将金属单壁碳纳米管（mCNT）电极共价结合到单个DNA双链体以产生mCNT-DNA-mCNT纳米结来控制电极分离，其中差距与DNA长度精确匹配。然后将这些结与自上而下的光刻技术相结合，以创建单分子电路，该电路具有由结中的DNA主导的电子特性，具有低分散的可再现电导值，并且足够稳定和坚固，可以用作活性，高特异性电子生物传感器，用于特定寡核苷酸的动态单分子检测，例如与SARS-CoV-2基因组相关的那些。这种可扩展的纳米级器件的高产量集成方法将为广泛应用的混合电子系统的制造提供机会。
Robust, high-yield integration of nanoscale components such as graphene nanoribbons, nanoparticles, or single-molecules with conventional electronic circuits has proven to be challenging. This difficulty arises because the contacts to these nanoscale devices must be precisely fabricated with angstrom-level resolution to make reliable connections, and at manufacturing scales this cannot be achieved with even the highest-resolution lithographic tools. Here we introduce an approach that circumvents this issue by precisely creating nanometer-scale gaps between metallic carbon electrodes by using a self-aligning, solution-phase process, which allows facile integration with conventional electronic systems with yields approaching 50%. The electrode separation is controlled by covalently binding metallic single-walled carbon nanotube (mCNT) electrodes to individual DNA duplexes to create mCNT-DNA-mCNT nanojunctions, where the gap is precisely matched to the DNA length. These junctions are then integrated with top-down lithographic techniques to create single-molecule circuits that have electronic properties dominated by the DNA in the junction, have reproducible conductance values with low dispersion, and are stable and robust enough to be utilized as active, high-specificity electronic biosensors for dynamic single-molecule detection of specific oligonucleotides, such as those related to the SARS-CoV-2 genome. This scalable approach for high-yield integration of nanometer-scale devices will enable opportunities for manufacturing of hybrid electronic systems for a wide range of applications.