Latest maintenance data on lithium in bipolar disorder
Latest maintenance data on lithium in bipolar disorder
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DOI：
10.1016/s0924-977x(03)00078-6
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发表时间：
2003-08-01
影响因子：
5.6
通讯作者：
Geddes, JR
中科院分区：
文献类型：
--
作者：
Goodwin, GM;Geddes, JR
虽然锂通常被认为是双相情感障碍维持治疗的金标准，但其有效性的证据仅基于少数充分设计的研究。拉莫三嗪双极试验的结果，包括锂作为活性对照，将大大增加长期锂治疗的信心。在这些数据的荟萃分析中，锂在预防双相情感障碍患者复发方面比安慰剂显著更有效（相对风险[RR] 0.65; 95%置信区间[CI] 0.50，0.84）。此外，锂对躁狂复发具有显著疗效（RR 0.61; 95% CI 0.39，0.95），对抑郁复发的作用不太显著，无统计学显著性（RR 0.72; 95% CI 0.49，1.07）。在选择锂维持治疗时，应考虑疾病亚型、治疗方案依从性、耐受性和剂量不确定性等因素。(C)2003年Elsevier B. V./© 2019 www.cnp.com版权所有
Although lithium is generally considered to be the gold standard for maintenance therapy in bipolar disorder, evidence of its efficacy has rested on only a small number of adequately designed studies. Results from the lamotrigine bipolar trials, which included lithium as an active comparator, will substantially increase confidence in long-term lithium treatment. In a meta-analysis of these data, lithium was significantly more effective than placebo in preventing relapse in patients with bipolar disorder (relative risk [RR] 0.65; 95% confidence interval [CI] 0.50, 0.84). Furthermore, lithium had significant efficacy against manic relapse (RR 0.61; 95% CI 0.39, 0.95), with a less substantial, not statistically significant, effect against depressive relapse (RR 0.72; 95% CI 0.49, 1.07). Factors such as disease subtype, likelihood of adherence to treatment regimen, tolerability, and dose uncertainty should be considered in the selection of lithium maintenance therapy. (C) 2003 Elsevier B.V./ECNP All rights reserved.