Natural history of acute and chronic hepatitis C
Natural history of acute and chronic hepatitis C
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DOI：
10.1016/j.bpg.2012.09.009
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发表时间：
2012-08-01
影响因子：
3.2
通讯作者：
Wedemeyer, Heiner
中科院分区：
文献类型：
--
作者：
Maasoumy, Benjamin;Wedemeyer, Heiner
丙型肝炎病毒（HCV）感染仍然是全球主要的健康负担。丙型肝炎由于肝失代偿和肝细胞癌的发展而导致显著的肝脏相关的发病率和死亡率。此外，丙型肝炎的肝外表现也很常见。在急性和慢性丙型肝炎的自然史中存在非常大的个体间变异性，这可以部分解释为各种宿主，病毒和环境因素的组合。成功的抗病毒治疗可以预防许多患者的HCV感染的短期和长期并发症。尽管如此，在HCV感染的不同阶段疾病进展的不同危险因素的相对贡献需要更好地定义。HCV感染的个性化治疗方法应考虑个体风险特征，以避免治疗不足和过度-这在即将到来的丙型肝炎无干扰素治疗时代仍然很重要。(c)2012爱思唯尔有限公司出版
Hepatitis C virus (HCV) infection remains a major global health burden. Hepatitis C causes significant liver-related morbidity and mortality due to hepatic decompensation and development of hepatocellular carcinoma. In addition, extra-hepatic manifestations of hepatitis C are frequent. There is a very large interindividual variability in the natural history of both acute and chronic hepatitis C which can be explained in part by a combination of various host, viral and environmental factors. Successful antiviral treatment can prevent short- and long-term complications of HCV infection in many patients. Still, the relative contribution of distinct risk factors for disease progression in different phases of HCV infection needs to be better defined. Personalized treatment approaches for HCV infection should consider individual risk profiles to avoid both under- and over-treatment - which will remain important also in upcoming era of interferon-free treatment of hepatitis C. (c) 2012 Published by Elsevier Ltd.