Biobehavioral factors and cancer progression: physiological pathways and mechanisms.
Biobehavioral factors and cancer progression: physiological pathways and mechanisms.
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DOI：
10.1097/psy.0b013e318235be76
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发表时间：
2011-11
影响因子：
3.3
通讯作者：
Sood AK
中科院分区：
文献类型：
--
作者：
Lutgendorf SK;Sood AK
流行病学证据越来越多地支持生物行为风险因素，如社会逆境，抑郁和压力在癌症进展中的作用。这篇综述描述了体外，体内和临床研究证明这些过程和参与癌症进展的途径之间的关系。这些包括对细胞免疫应答、血管生成、侵袭、失巢凋亡和炎症的影响。生物行为因素已被证明有助于肿瘤微环境中肿瘤和宿主细胞之间的串扰，并且对宿主细胞如巨噬细胞的应激效应似乎对参与肿瘤进展的许多途径至关重要。一些效应是双向的，因为肿瘤衍生的炎症似乎影响中枢神经系统过程，引起植物性症状并导致HPA轴的失调，对炎症控制具有下游效应。迄今为止的调查结果进行了审查和富有成效的领域，为今后的研究进行了讨论。
Epidemiological evidence increasingly has supported the role of biobehavioral risk factors such as social adversity, depression, and stress in cancer progression. This review describes in vitro, in vivo, and clinical studies demonstrating relationships between such processes and pathways involved in cancer progression. These include effects on the cellular immune response, angiogenesis, invasion, anoikis, and inflammation. Biobehavioral factors have been shown to contribute to the cross-talk between tumor and host cells in the tumor microenvironment and stress effects on host cells such as macrophages appear to be critical for many pathways involved in tumor progression. Some effects are bi-directional, in that tumor derived inflammation appears to affect central nervous system processes, giving rise to vegetative symptoms and contributing to dysregulation of the HPA axis with downstream effects on inflammatory control. Findings to date are reviewed and fruitful areas for future research are discussed.