Protein O-GlcNAcylation in diabetes and diabetic complications.
Protein O-GlcNAcylation in diabetes and diabetic complications.
复制标题
糖尿病和糖尿病并发症的蛋白O-Glcnacylation。
DOI：
10.1586/14789450.2013.820536
复制
发表时间：
2013-08
影响因子：
3.4
通讯作者：
Hart GW
中科院分区：
文献类型：
--
作者：
Ma J;Hart GW
O-连接β-N-乙酰氨基葡萄糖(O-GlcNAc)对蛋白质丝氨酸和苏氨酸残基的翻译后修饰是高度普遍的、动态的和诱导的。蛋白质O-GlcN酰化是转录、翻译、蛋白酶体降解、信号转导和细胞凋亡等关键生物学过程的关键调节因子。O-GlcN酰化增加直接与胰岛素抵抗和高血糖引起的葡萄糖毒性有关，这是糖尿病和糖尿病并发症的两个特征。本文简要综述了蛋白质O-GlcN酰化与营养代谢的关系，并讨论了在培养细胞和动物模型中检测O-GlcN酰化变化的常用工具。然后我们将重点放在O-GlcNAc修饰的一些关键蛋白上，这些蛋白在糖尿病和糖尿病并发症的病因和进展中发挥关键作用。蛋白质组学方法也被强调，以提供蛋白质O-GlcN酰化的系统观点。最后，我们讨论了如何利用某些蛋白质上异常的O-GlcN酰化来开发糖尿病前期和/或糖尿病的早期诊断方法。
The post-translational modification of serine and threonine residues of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) is highly ubiquitous, dynamic and inducible. Protein O-GlcNAcylation serves as a key regulator of critical biological processes including transcription, translation, proteasomal degradation, signal transduction and apoptosis. Increased O-GlcNAcylation is directly linked to insulin resistance and to hyperglycemia-induced glucose toxicity, two hallmarks of diabetes and diabetic complications. In this review, we briefly summarize what is known about protein O-GlcNAcylation and nutrient metabolism, as well as discuss the commonly used tools to probe changes of O-GlcNAcylation in cultured cells and in animal models. We then focus on some key proteins modified by O-GlcNAc, which play crucial roles in the etiology and progression of diabetes and diabetic complications. Proteomic approaches are also highlighted to provide a system view of protein O-GlcNAcylation. Finally, we discuss how aberrant O-GlcNAcylation on certain proteins may be exploited to develop methods for the early diagnosis of pre-diabetes and/or diabetes.
登录
查看更多内容
DOI：
10.1073/pnas.1200425109
发表时间：
2012-05-08
影响因子：
11.1
作者：
Alfaro, Joshua F.;Gong, Cheng-Xin;Smith, Richard D.
通讯作者：
Smith, Richard D.
影响因子：
4.8
作者：
Chang, Q;Su, KH;Kudlow, JE
通讯作者：
Kudlow, JE
影响因子：
3.7
作者：
Ande, Sudharsana R.;Moulik, Saby;Mishra, Suresh
通讯作者：
Mishra, Suresh
影响因子：
4.8
作者：
Anthonisen, Elin Holter;Berven, Lise;Gronning-Wang, Line M.
通讯作者：
Gronning-Wang, Line M.
影响因子：
2.9
作者：
Comer, FI;Vosseller, K;Hart, GW
通讯作者：
Hart, GW