Evaluation of recombinant CXCL8((3-73))K11R/G31P in muscle fibrosis and Trichinella larvae encapsulation in a murine model of trichinellosis
Evaluation of recombinant CXCL8((3-73))K11R/G31P in muscle fibrosis and Trichinella larvae encapsulation in a murine model of trichinellosis
复制标题
重组CXCL8((3-73))K11R/G31P对旋毛虫病小鼠模型肌肉纤维化和旋毛虫幼虫包囊的评价
DOI：
10.1016/j.intimp.2016.03.047
复制
发表时间：
2016
影响因子：
5.6
通讯作者：
Cui Yu
中科院分区：
文献类型：
--
作者：
Yan Wenhui;Li Fang;Qin Yuanhua;Ren Yixin;Zheng Lili;Dai Xiaodong;Mao Weifeng;Cui Yu
Trichinella spiralis (T. spiralis) larvae in raw or inadequately cooked meat can cause chronic infections in a wide range of hosts including humans. During the development inside the skeletal muscles,T. spiralislarvae infect muscle cells accompanying with the infiltration of host inflammatory cells, eventually create a new type of cell known as nurse cell developing a surrounding vascular network to support the larvae development. Controlling of host inflammatory responses and angiogenesis influences both the nurse cell differentiation and the parasite larvae development. CXCL8 is a chemokine that acts on G-protein coupled receptors, of which activation contributes to fibrosis and angiogenesis. CXCL8(3–73)K11R/G31P (G31P) has been reported as a CXCL8 analogue. The aim of this study is to investigate the effect of G31P in inflammatory responses and the development ofT. spiralislarvae in muscle tissues of mice infected withT. spiralis. The level of inflammatory factors and the morphology ofT. spiralislarvae in infected tissues were investigated through ELISA and electron-microscopy analysis. G31P up-regulated IFN-γ and down-regulated CXCL8 level, and impaired the encapsulation ofT. spiralislarvaein vivo. The results showed that G31P influenced the development ofT. spiralislarvae in muscle tissues.
