Chinese Medicine for Psoriasis Vulgaris Based on Syndrome Pattern: A Network Pharmacological Study
Chinese Medicine for Psoriasis Vulgaris Based on Syndrome Pattern: A Network Pharmacological Study
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基于证候的中药治疗寻常型银屑病：网络药理学研究
DOI：
10.1155/2020/5239854
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发表时间：
2020-04-28
影响因子：
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通讯作者：
Gu, Jiangyong
中科院分区：
文献类型：
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作者：
Wang, Dongmei;Lu, Chuanjian;Gu, Jiangyong
背景寻常型银屑病的长期使用传统疗法仍然是一个挑战，因为患者的反应有限或没有反应，且有严重的副作用。补充和替代疗法，如传统中医药，在东亚被广泛使用。中医治疗以个体证型为主。复方青黛丸(F1)、鱼金银屑片(F2)、消银片(F3)分别用于治疗血热型、血瘀型、血燥型寻常型银屑病。目的探讨三方治疗寻常型银屑病三种证型的作用机制。方法从寻常型银屑病数据库中检索到3个中药方剂的化合物。通过分析化合物在化学空间中的分布，比较了它们的吸收、分布、代谢、排泄和毒性(ADME/T)以及类药物的分子性质。通过分子对接预测了化合物的细胞靶点。通过构建化合物靶标网络，分析网络中心性，筛选出各配方的关键靶标和化合物。三种类型的寻常型银屑病相关路径和生物学过程(BPS)由注释、可视化和综合发现数据库(David)v6.8丰富。结果3个处方的化合物具有结构多样性、良好的类药物性质和ADME/T性质。共有72个、97个和85个靶点分别与F1、F2和F3的化合物相互作用。这三个方程式都涉及53个靶点、8条途径、9个生物过程和10个分子功能(MFS)。此外，每个公式都有独特的靶点，并调节不同的途径和BP。结论三个方剂在一定程度上具有共同的作用机制。分子和系统水平上的差异可能有助于它们在个体化治疗中的独特应用。
Background The long-term use of conventional therapy for psoriasis vulgaris remains a challenge due to limited or no patient response and severe side effects. Complementary and alternative treatments such as traditional Chinese medicine (TCM) are widely used in East Asia. TCM treatment is based on individual syndrome types. Three TCM formulae, Compound Qingdai Pills (F1), Yujin Yinxie Tablets (F2), and Xiaoyin Tablets (F3), are used for blood heat, blood stasis, and blood dryness type of psoriasis vulgaris, respectively. Objectives To explore the mechanism of three TCM formulae for three syndrome types of psoriasis vulgaris. Methods The compounds of the three TCM formulae were retrieved from the Psoriasis Database of Traditional Chinese Medicine (PDTCM). Their molecular properties of absorption, distribution, metabolism, excretion and toxicity (ADME/T), and drug-likeness were compared by analyzing the distribution of compounds in the chemical space. The cellular targets of the compounds were predicted by molecular docking. By constructing the compound-target network and analyzing network centrality, key targets and compounds for each formula were screened. Three syndrome types of psoriasis vulgaris related pathways and biological processes (BPs) were enriched by the Database for Annotation, Visualization, and Integrated Discovery (DAVID) v6.8. Results The compounds of the three formulae exhibited structural diversity, good drug-like properties, and ADME/T properties. A total of 72, 97 and 85 targets were found to have interactions with compounds of F1, F2, and F3, respectively. The three formulae were all related to 53 targets, 8 pathways, 9 biological processes, and 10 molecular functions (MFs). In addition, each formula had unique targets and regulated different pathways and BPs. Conclusion The three TCM formulae exhibited common mechanisms to some extent. The differences at molecular and systems levels may contribute to their unique applications in individualized treatment.