CELL-CULTURE AGING
CELL-CULTURE AGING
复制标题
DOI：
10.1007/bf02357034
复制
发表时间：
1981-01-01
影响因子：
4.3
通讯作者：
SCHNEIDER, EL
中科院分区：
文献类型：
--
作者：
REFF, M;SCHNEIDER, EL
Cellular research in aging has been stimulated by the observation that human diploid cells have a limited number of cell divisions in culture. This loss of cellular proliferation (in vitrosenescence) has been extensively studied by biochemical, clonal, and genetic analysis. Studies of human skin fibroblast cultures have revealed thatin vitrosenescense is related toin vivohuman cellular aging. Recently differentiated cells have been proposed for aging studies. These cells may provide additional information on aging since alterations ofin vitrocellular functions may be related to thein vivobehavior of specific differented cell types.
