Notch in malignancy.
Notch in malignancy.
复制标题
DOI：
10.1007/0-306-48158-8_4
复制
发表时间：
2003
影响因子：
--
通讯作者：
D. Ball;S. Leach
中科院分区：
文献类型：
--
作者：
D. Ball;S. Leach
Notch信号通路作为一种功能极为广泛的发育开关，在生物学中扮演着重要的角色。在不同的多细胞生物体中，Noch信号控制着许多细胞的命运和分化决定。Notch在癌症中作用的新概念反映了这一途径在调节癌症前体细胞的表型以及Notch调节生长和作为癌基因作用的能力方面的重要性。我们将总结Notch信号机制的基本特征，以及Notch在胎儿发育和出生后干细胞中作用的几个研究很好的例子。这篇综述的重点将集中在Notch作为癌基因，作为癌症表型的主要决定因素，以及作为药物治疗的潜在靶点。
The Notch signaling pathway plays a remarkable role in biology as a superbly versatile developmental switch. Notch signaling controls numerous cell fate and differentiation decisions in divergent multicellular organisms. Emerging concepts of Notch action in cancer reflect the importance of this pathway in regulating the phenotype of cancer progenitor cells and the capacity of Notch to regulate growth and to act as an oncogene. We will summarize essential features of Notch signaling mechanisms and several well-studied examples of Notch actions in fetal development and post-natal stem cells. The balance of this review will focus on Notch as an oncogene, as a major determinant of the cancer phenotype, and as a potential target for drug therapy.