Larrea tridentata: A novel source for antiparasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri
Larrea tridentata: A novel source for antiparasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri
复制标题
DOI：
10.1371/journal.pntd.0005832
复制
发表时间：
2017-08-01
影响因子：
3.8
通讯作者：
LaBarbera, Daniel V.
中科院分区：
文献类型：
--
作者：
Bashyal, Bharat;Li, Linfeng;LaBarbera, Daniel V.
原生动物寄生虫每年感染并杀死全世界数百万人，特别是在清洁淡水有限的发展中国家。其中最常见的是肠道寄生虫，包括贾第虫和溶组织内阿米巴。这些寄生虫对小肠上皮细胞造成严重破坏（G。lamblia）和结肠（E.溶组织菌）分别引起贾第虫病和阿米巴病。此外，还有一些不太常见但致命得多的病原体，如福氏耐格里虫，它们在温暖的沃茨中繁殖，并通过鼻腔感染受害者的中枢神经系统。尽管它们的流行率和相关的高死亡率，但仍然需要为感染这些机会性寄生虫的人确定更有效的治疗方法。为了解决这一未满足的需求，我们对世界各地已知的植物和传统草药进行了调查，以确定对G. lamblia，E. histolytica和N.福勒里在此，我们报告Larrea tridentata，被称为杂酚油布什，作为一种新的来源的次生代谢产物，显示抗寄生虫活性对所有三种病原体。该报告还描述了木脂素类化合物，去甲二氢愈创木酸和去甲氧基异愈创木酸，作为新型抗寄生虫药的主要药物，以进一步为全球数百万人开发更有效的药物治疗选择。
Protozoan parasites infect and kill millions of people worldwide every year, particularly in developing countries where access to clean fresh water is limited. Among the most common are intestinal parasites, including Giardia lamblia and Entamoeba histolytica. These parasites wreak havoc on the epithelium lining the small intestines (G. lamblia) and colon (E. histolytica) causing giardiasis and amebiasis, respectively. In addition, there are less common but far more deadly pathogens such as Naegleria fowleri that thrive in warm waters and infect the central nervous systems of their victims via the nasal passages. Despite their prevalence and associated high mortality rates, there remains an unmet need to identify more effective therapeutics for people infected with these opportunistic parasites. To address this unmet need, we have surveyed plants and traditional herbal medicines known throughout the world to identify novel antiparasitic agents with activity against G. lamblia, E. histolytica, and N. fowleri. Herein, we report Larrea tridentata, known as creosote bush, as a novel source for secondary metabolites that display antiparasitic activity against all three pathogens. This report also characterizes the lignan compound classes, nordihydroguairetic acid and demethoxyisoguaiacin, as novel antiparasitic lead agents to further develop more effective drug therapy options for millions of people worldwide.