Responses of differentiated primary human lung epithelial cells to exposure to diesel exhaust at an air-liquid interface.
Responses of differentiated primary human lung epithelial cells to exposure to diesel exhaust at an air-liquid interface.
复制标题
分化的原代人肺上皮细胞对气液界面暴露于柴油废气的反应。
DOI：
10.1080/01902140601113088
复制
发表时间：
2007
影响因子：
1.7
通讯作者：
Stidley,Christine
中科院分区：
文献类型：
--
作者：
Seagrave,JeanClare;Dunaway,Sandy;McDonald,JacobD;Mauderly,JoeL;Hayden,Patrick;Stidley,Christine
在生理条件下，潜在的靶细胞类型对空气污染物的体外反应可能有助于了解空气污染暴露对健康的影响。本研究评估了人原代气道上皮细胞对柴油机尾气（DE）的反应。将来自3个供体的细胞培养物暴露于过滤空气或DE，所述细胞培养物通过在顶面暴露于大气的膜上培养而分化。一些与供体相关的影响是相似的，而另一些则受到供体的影响，这与人群异质性一致。该模型可用于机制和比较毒理学研究。
In vitro responses of potential target cell types to air pollutants under physiological conditions may be useful in understanding the health effects of air pollution exposure. The study evaluated responses of human primary airway epithelial cells to diesel exhaust (DE). Cultures of cells from 3 donors, differentiated by culture on membranes with the apical surfaces exposed to the atmosphere, were exposed to filtered air or DE. Some exposure-related effects were similar among donors, whereas others were affected by the donor, consistent with human population heterogeneity. This model may be useful for mechanistic and comparative toxicology studies.