External cavity laser biosensor.
External cavity laser biosensor.
复制标题
DOI：
10.1039/c3lc41330f
复制
发表时间：
2013-04-07
期刊：
影响因子：
6.1
通讯作者：
Cunningham BT
中科院分区：
文献类型：
--
作者：
Ge C;Lu M;George S;Flood TA Jr;Wagner C;Zheng J;Pokhriyal A;Eden JG;Hergenrother PJ;Cunningham BT
利用可调谐光子晶体谐振反射器作为外腔激光腔的镜子，我们展示了一种新型无标记光学生物传感器，该传感器通过受激发射过程实现了高品质因数，同时提供高灵敏度和大动态范围。光子晶体由塑料材料制成，成本低廉，其谐振波长通过其表面生物分子的吸附来调节。激光过程的增益由半导体光学放大器提供，从而形成一种简单的检测仪器，该仪器通过光子晶体的正常入射非接触照明和直接背向反射到放大器中进行操作。我们演示了单模、生物分子诱导的连续波激光波长调谐。由于该方法采用了与传感器分离的外部光学增益，因此该设备比以前的无源光学谐振器生物传感器和基于激光的生物传感器取得了重大进步。
Utilizing a tunable photonic crystal resonant reflector as a mirror of an external cavity laser cavity, we demonstrate a new type of label-free optical biosensor that achieves a high quality factor through the process of stimulated emission, while at the same time providing high sensitivity and large dynamic range. The photonic crystal is fabricated inexpensively from plastic materials, and its resonant wavelength is tuned by adsorption of biomolecules on its surface. Gain for the lasing process is provided by a semiconductor optical amplifier, resulting in a simple detection instrument that operates by normally incident noncontact illumination of the photonic crystal and direct back-reflection into the amplifier. We demonstrate single-mode, biomolecule-induced tuning of the continuous-wave laser wavelength. Because the approach incorporates external optical gain that is separate from the transducer, the device represents a significant advance over previous passive optical resonator biosensors and laser-based biosensors.