Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus
Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus
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DOI：
10.4269/ajtmh.2006.75.994
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发表时间：
2006-11-01
影响因子：
3.3
通讯作者：
Arikawa, Jiro
中科院分区：
文献类型：
--
作者：
Pattamadilok, Sirima;Lee, Byoung-Hee;Arikawa, Jiro
系统发育调查，序列比较和抗原交叉反应活性的研究证实了泰国病毒（THAIV）作为一个独特的汉坦病毒种的分类。对泰国19个省捕获的402只啮齿动物的血清进行检测，发现5只大袋狸（Bandicota indica）和1只小袋狸（B. savilei）为THAIV的焦点减少中和试验（FRNT）阳性。来自泰国素林省的260名患者中有一名（最初怀疑感染了钩端螺旋体病，但发现为阴性）表现出与肾综合征出血热（HFRS）相符的症状。该患者的血清显示高滴度的汉他病毒反应性IgM和IgG。FRNT调查证实了针对THAIV的病毒中和抗体。这些观察结果表明，THAIV或THAI样病毒发生在整个印度支那，并可能代表HFRS的另一种病原体。
Phylogenetic investigations, sequence comparisons, and antigenic cross-re activity studies confirmed the classification of Thailand virus (THAIV) as a distinct hantavirus species. The examination of sera from 402 rodents trapped in 19 provinces of Thailand revealed that five greater bandicoot rats (Bandicota indica) and one lesser bandicoot rat (B. savilei) from four provinces were focus reduction neutralization test (FRNT) antibody-positive for THAIV. One of 260 patients from Surin province in Thailand (initially suspected of having contracted leptospirosis, but found to be negative) showed symptoms compatible with hemorrhagic fever with renal syndrome (HFRS). The serum of this patient showed high titers of hantavirus-reactive IgM and IgG. FRNT investigations confirmed virus-neutralizing antibodies against THAIV. These observations suggest that THAIV or THAI-like viruses occur throughout Indochina and may represent an additional causative agent of HFRS.