SARS-CoV-2 spike protein removes lipids from model membranes and interferes with the capacity of high density lipoprotein to exchange lipids.
SARS-CoV-2 spike protein removes lipids from model membranes and interferes with the capacity of high density lipoprotein to exchange lipids.
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DOI：
10.1016/j.jcis.2021.06.056
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发表时间：
2021-11-15
影响因子：
9.9
通讯作者：
Cárdenas M
中科院分区：
文献类型：
--
作者：
Correa Y;Waldie S;Thépaut M;Micciulla S;Moulin M;Fieschi F;Pichler H;Trevor Forsyth V;Haertlein M;Cárdenas M
胆固醇已被证明会影响冠状病毒与细胞膜结合和融合的程度。据了解，Covid-19 感染的严重程度也与血脂紊乱相关。此外，血清胆固醇和高密度脂蛋白 (HDL) 的水平随着 Covid-19 的严重程度而降低，一旦感染过去，就会恢复正常水平。在这里，我们证明 SARS-CoV-2 刺突 (S) 蛋白会干扰脂蛋白的功能，并且这取决于胆固醇。特别是，当与刺突蛋白共孵育时，HDL 从模型细胞膜交换脂质的能力会发生改变。此外，S 蛋白还能去除模型膜上的脂质和胆固醇。我们认为，S 蛋白通过去除其中的脂质并重塑其组成/结构来影响 HDL 功能。
Cholesterol has been shown to affect the extent of coronavirus binding and fusion to cellular membranes. The severity of Covid-19 infection is also known to be correlated with lipid disorders. Furthermore, the levels of both serum cholesterol and high-density lipoprotein (HDL) decrease with Covid-19 severity, with normal levels resuming once the infection has passed. Here we demonstrate that the SARS-CoV-2 spike (S) protein interferes with the function of lipoproteins, and that this is dependent on cholesterol. In particular, the ability of HDL to exchange lipids from model cellular membranes is altered when co-incubated with the spike protein. Additionally, the S protein removes lipids and cholesterol from model membranes. We propose that the S protein affects HDL function by removing lipids from it and remodelling its composition/structure.
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