Association between premature ovarian failure, polymorphisms in MTHFR and MTRR genes and serum homocysteine concentration
Association between premature ovarian failure, polymorphisms in MTHFR and MTRR genes and serum homocysteine concentration
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DOI：
10.1016/j.rbmo.2016.01.009
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发表时间：
2016-04-01
影响因子：
4
通讯作者：
Xu, Chenming
中科院分区：
文献类型：
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作者：
Hou, Ningning;Chen, Songchang;Xu, Chenming
本研究旨在探讨卵巢早衰（POF）与MTHFR C677 T/A1298 C和MTRR A66 G基因型及血清同型半胱氨酸（Hcy）浓度的关系。在中国女性中进行了一项前瞻性研究，其中包括POF患者（n = 180）和对照组（n = 195）。检测MTHFR C677 T/A1298 C和MTRR A66 G基因型、血清Hcy和性激素水平。结果显示，POF患者血清Hcy浓度明显高于对照组（P < 0.0001）。POF患者血清Hcy水平与雌二醇、FSH水平呈显著正相关（分别为r =-0.174，P = 0.037和r =+0.238，P = 0.006）。MTHFR C677 T/A1298 C和MTRR A66 G基因型在两组间的分布差异无统计学意义。但这些基因变异对POF患者血清Hcy浓度有影响，尤其是MTRR 66 AA/AG/GG基因型与患者血清Hcy浓度显著相关（tau = 0.166，P = 0.033）。提示POF患者血清Hcy水平升高，且与血清雌二醇/FSH水平相关。MTHFR C667 T/A1298 C和MTRR A66 G基因型与POF的发生无关，但影响患者血清Hcy浓度。(C)2016生殖保健有限公司由爱思唯尔有限公司出版。版权所有。
This study investigated the association between premature ovarian failure (POF), MTHFR C677T/A1298C and MTRR A66G genotypes and serum homocysteine (Hcy) concentration. A prospective study was conducted in Chinese women, which included POF patients (n = 180) and controls (n = 195). Peripheral blood samples were used to determine MTHFR C677T/A1298C and MTRR A66G genotypes, and serum Hcy and sex hormone concentrations. Results showed that serum Hcy concentrations of POF patients were significantly higher than those of controls (P < 0.0001). In POF patients, serum Hcy concentrations were significantly correlated with oestradiol and FSH concentrations (r = -0.174, P = 0.037 and r = +0.238, P = 0.006, respectively). There were no significant differences in the distributions of MTHFR C677T/A1298C or MTRR A66G genotypes between the two groups. However, these genetic variants influenced serum Hcy concentrations in POF patients, especially for MTRR 66 AA/AG/GG genotypes, which were significantly correlated with the patients' Hcy concentrations (tau = 0.166, P = 0.033). These results suggest that serum Hcy concentrations in Chinese POF patients are increased and correlated with serum oestradiol/FSH concentrations. In conclusion, MTHFR C667T/A1298C and MTRR A66G genotypes are not associated with POF development, but they affect the patients' serum Hcy concentrations. (C) 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.