Variability: The common factor linking low dose-induced genomic instability, adaptation and bystander effects
Variability: The common factor linking low dose-induced genomic instability, adaptation and bystander effects
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DOI：
10.1016/j.mrfmmm.2006.11.016
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发表时间：
2007-03-01
影响因子：
2.3
通讯作者：
Schwartz, Jeffrey L.
中科院分区：
文献类型：
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作者：
Schwartz, Jeffrey L.
低剂量辐射诱导的基因组不稳定性，适应性反应和旁观者效应的特点进行了比较，以探讨可能的潜在机制，并开发模型预测体内低剂量辐射照射的反应。虽然有一些特征是所有三个共同的（例如，不存在真实的剂量-反应，多个终点受每个终点的影响），其它特征似乎将一个与另一个区分开（例如，TP 53参与，LET反应，DNA修复的影响）。每个响应也是高度可变的;并非所有细胞和组织模型都显示出相同的响应，并且响应存在很大的个体间差异。这些研究大多采用体外细胞培养或组织外植体模型，了解这些低剂量反应的潜在机制和生物学意义将需要研究组织特异性体内终点。体外研究强烈表明，低剂量辐射效应建模将是一个复杂的过程，可能需要对这些低剂量现象中的每一种进行单独研究。例如，不稳定性响应的知识可能无助于预测同一组织中的其他低剂量效应。(c)2006年由Elsevier B. V.出版
The characteristics of low dose radiation-induced genomic instability, adaptive responses, and bystander effects were compared in order to probe possible underlying mechanisms, and develop models for predicting response to in vivo low dose radiation exposures. While there are some features that are common to all three (e.g., absence of a true dose-response, the multiple endpoints affected by each), other characteristics appear to distinguish one from the other (e.g., TP53 involvement, LET response, influence of DNA repair). Each of the responses is also highly variable; not all cell and tissue models show the same response and there is much interindividual variation in response. Most of these studies have employed in vitro cell culture or tissue explant models, and understanding underlying mechanisms and the biological significance of these low dose-responses will require study of tissue-specific in vivo endpoints. The in vitro studies strongly suggest that modeling low dose radiation effects will be a complex process, and will likely require separate study of each of these low dose phenomena. Knowledge of instability responses, for example, may not aid in predicting other low dose effects in the same tissue. (c) 2006 Published by Elsevier B.V.