EFFECTS OF ANALOGS OF ADENOSINE AND METHYL XANTHINES ON INSULIN SENSITIVITY IN SOLEUS MUSCLE OF THE RAT
EFFECTS OF ANALOGS OF ADENOSINE AND METHYL XANTHINES ON INSULIN SENSITIVITY IN SOLEUS MUSCLE OF THE RAT
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DOI：
10.1016/0014-5793(84)80820-0
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发表时间：
1984-01-01
期刊：
影响因子：
3.5
通讯作者：
NEWSHOLME, EA
中科院分区：
文献类型：
--
作者：
BUDOHOSKI, L;CHALLISS, RAJ;NEWSHOLME, EA
腺苷类似物2-氯腺苷和N6-苯基异丙基腺苷可显著增加剥离比目鱼肌制备物产生糖酵解半数最大刺激的胰岛素浓度，但甲基黄嘌呤类似物8-苯基茶碱可显著降低胰岛素浓度。2-氯腺苷将刺激糖酵解所需的胰岛素浓度增加一半，从约100 μ单位/ml增加到2000 μ单位/ml。8-苯基茶碱将胰岛素浓度从约100 μ单位/ml降低至10 μ单位/ml，这一作用类似于向培养基中添加腺苷脱氨酶或对供体动物进行4周运动训练所产生的作用。
The concentration of insulin that produces half‐maximal stimulation of glycolysis by stripped soleus muscle preparations is markedly increased by the adenosine analogues, 2‐chloroadenosine andN6‐phenylisopropyladenosine, but is markedly decreased by the methyl xanthine analogue, 8‐phenyltheophylline. 2‐Chloroadenosine increases the concentration of insulin required to stimulate glycolysis half maximally, from about 100 to 2000 μunits/ml. 8‐Phenyltheophylline decreases this concentration of insulin from about 100 to 10 μunits/ml, an effect which is similar to that produced either by addition of adenosine deaminase to the medium or to exercise‐training of the donor animals for 4 weeks.