Age-, gender-, and weight-related effects on levels of 25-hydroxyvitamin D are not mediated by vitamin D binding protein
Age-, gender-, and weight-related effects on levels of 25-hydroxyvitamin D are not mediated by vitamin D binding protein
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DOI：
10.1111/j.1365-2265.2007.02873.x
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发表时间：
2007-08-01
影响因子：
3.2
通讯作者：
Reid, Ian R.
中科院分区：
文献类型：
--
作者：
Bolland, Mark J.;Grey, Andrew B.;Reid, Ian R.
目的25-羟维生素D（25 OHD）水平与体重呈负相关，并已报道随着年龄的增长而下降，女性低于男性。我们假设这些发现可能是通过这些变量对维生素D结合蛋白（DBP）水平的影响来解释的。我们着手确定DBP与性别、25 OHD、体重和身体成分之间的关系。设计横断面分析。患者100名健康、中年和老年、社区居住的男性和女性。测量所有参与者测量25 OHD、DBP、体重、骨矿物质密度和身体成分。结果女性平均DBP水平高于男性，但总25 OHD水平较低[DBP：女性，平均（SD）339（36）mg/l，男性307（71）mg/l，P = 0.005; 25 OHD：女性67（23）nmol/l，男性91（39）nmol/l，P < 0.001]。在女性中，DBP与白蛋白（r = 0.33）和25 OHD（r = 0.34）之间存在显著正相关，而在男性中，DBP与任何测量变量之间均无显著相关性。DBP与年龄、体重、体重指数、脂肪量或脂肪百分比在男性或女性中无显著关系。结论我们没有发现任何证据支持DBP水平与年龄或肥胖有关的假设。25 OHD水平随年龄、性别或脂肪量的变化不是由于DBP和这些变量之间的潜在关系。这表明，25 OHD和身体组成和性别之间的关系始终观察到的生物起源，而不是由于适应运输蛋白的变化。
Objective 25-hydroxyvitamin D (25OHD) levels are inversely related to body weight, and have been reported to decline with age and be lower in women than men. We hypothesized that these findings might be explained by effects of these variables on vitamin D binding protein (DBP) levels. We set out to determine the relationships between DBP and gender, 25OHD, body weight and body composition.Design Cross-sectional analysis.Patients One hundred healthy, middle-aged and older, community-dwelling men and women.Measurements All participants were measured for 25OHD, DBP, body weight, bone mineral density and body composition.Results Women had higher mean DBP levels than men but lower total 25OHD levels [DBP: women, mean (SD) 339 (36) mg/l, men 307 (71) mg/l, P = 0.005; 25OHD: women 67 (23) nmol/l, men 91 (39) nmol/l, P < 0.001]. In women, there were significant positive relationships between DBP and albumin (r = 0.33) and 25OHD (r = 0.34) whereas in men there were no significant relationships between DBP and any measured variables. There was no significant relationship between DBP and age, body weight, body mass index, fat mass or percentage fat in men or women.Conclusion We found no evidence to support the hypothesis that DBP levels are related to age, or adiposity. The changes in 25OHD levels with age, gender, or fat mass are not due to underlying relationships between DBP and these variables. This suggests that the relationships consistently observed between 25OHD and body composition and gender are of biological origin and not due to adaptation to changes in transport proteins.