Skeletal Stem Cells as the Developmental Origin of Cellular Niches for Hematopoietic Stem and Progenitor Cells.
Skeletal Stem Cells as the Developmental Origin of Cellular Niches for Hematopoietic Stem and Progenitor Cells.
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DOI：
10.1007/978-3-030-86016-5_1
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发表时间：
2021
影响因子：
--
通讯作者：
Chan CKF
中科院分区：
文献类型：
--
作者：
Ambrosi TH;Chan CKF
骨骼系统是间充质、造血和血管生成干细胞谱系的高度复杂的网络，其协调定义的微环境（所谓的生态位）的发育和维持。近年来的技术进步已经允许解剖关键细胞类型以及它们的自分泌和旁分泌信号，这些信号在发育，稳态，再生和疾病期间调节这些小生境。血管的进入和骨髓造血是由骨骼干细胞（SSC）及其更定向的下游谱系细胞类型启动的，这些细胞类型指导骨骼元素的形状和形式。在这一章中，我们集中在造血干细胞和祖细胞的小生境的发育起源的作用。我们讨论了SSC定义的最新更新，建立和维持壁龛的细胞过程，以及促进恶性肿瘤的干细胞微环境的改变。最后，我们展望了未来的研究，可以利用SSC-生态位工程的基础上开发新的治疗工具，不仅治疗骨相关疾病，但也源于脱轨的生态位动态改变造血输出的疾病。
The skeletal system is a highly complex network of mesenchymal, hematopoietic, and vasculogenic stem cell lineages that coordinate the development and maintenance of defined microenvironments, so-called niches. Technological advancements in recent years have allowed for the dissection of crucial cell types as well as their autocrine and paracrine signals that regulate these niches during development, homeostasis, regeneration, and disease. Ingress of blood vessels and bone marrow hematopoiesis are initiated by skeletal stem cells (SSCs) and their more committed downstream lineage cell types that direct shape and form of skeletal elements. In this chapter, we focus on the role of SSCs as the developmental origin of niches for hematopoietic stem and progenitor cells. We discuss latest updates in the definition of SSCs, cellular processes establishing and maintaining niches, as well as alterations of stem cell microenvironments promoting malignancies. We conclude with an outlook on future studies that could take advantage of SSC-niche engineering as a basis for the development of new therapeutic tools to not only treat bone-related diseases but also maladies stemming from derailed niche dynamics altering hematopoietic output.
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影响因子：
64.5
作者：
Baryawno, Ninib;Przybylski, Dariusz;Scadden, David T.
通讯作者：
Scadden, David T.
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1073/pnas.1411975111
发表时间：
2014-12-09
影响因子：
11.1
作者：
Bourgine, Paul E.;Scotti, Celeste;Martin, Ivan
通讯作者：
Martin, Ivan
影响因子：
64.8
作者：
Ambrosi TH;Marecic O;McArdle A;Sinha R;Gulati GS;Tong X;Wang Y;Steininger HM;Hoover MY;Koepke LS;Murphy MP;Sokol J;Seo EY;Tevlin R;Lopez M;Brewer RE;Mascharak S;Lu L;Ajanaku O;Conley SD;Seita J;Morri M;Neff NF;Sahoo D;Yang F;Weissman IL;Longaker MT;Chan CKF
通讯作者：
Chan CKF
影响因子：
2.1
作者：
BIDEGAIN, M;ROOS, BA;BALKAN, W
通讯作者：
BALKAN, W