On the distribution and genetic differentiation of Anopheles gambiae s.s. molecular forms
On the distribution and genetic differentiation of Anopheles gambiae s.s. molecular forms
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DOI：
10.1016/j.ibmb.2005.02.006
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发表时间：
2005-07-01
影响因子：
3.8
通讯作者：
Petrarca, V
中科院分区：
文献类型：
--
作者：
della Torre, A;Tu, ZJ;Petrarca, V
本文总结了已发表和未发表的数据的空间和时间分布，并对分子形式的冈比亚按蚊S. S的M和S的遗传特征。这两种形式的特点是基因流的高度限制，在很大程度上重叠的地理和时间分布，以及低程度的遗传分化。浮动的染色体2上的近着丝粒倒位被证明是共享的两种形式，虽然有非常不同的频率的替代安排，确认这些倒位是最有可能参与生态适应，而不是在建设的生殖障碍。还需要进一步研究和工具来阐明M和S的遗传和生物分化，以增进对病媒系统的真实的组成、其人口统计学、种群遗传学和动态的了解，并考虑到对人类病原体在撒哈拉以南非洲传播的可能后果。利用转座因子插入位点作为遗传分化的标记和群体遗传学研究的工具的初步结果和前景进行了讨论。(c)2005爱思唯尔有限公司保留所有权利。
This paper summarises published and unpublished data on the spatial and temporal distribution, and on the genetic characterisation of molecular forms M and S of Anopheles gambiae s.s. The two forms are characterised by a high level of gene-flow restriction, by a largely overlapping geographical and temporal distribution, and by a low degree of genetic differentiation. Floating paracentric inversions on chromosome-2 are shown to be shared by the two forms, although with very different frequencies of alternative arrangements, confirming that these inversions are most probably involved in ecotypic adaptation, rather than in the building of reproductive barriers. Further studies and tools are needed to throw light on the genetic and biological differentiation of M and S to improve the knowledge of the real composition of the vector system, of its demography, population genetics and dynamics, also in view of the possible consequences on the transmission of human pathogens in sub-Saharan Africa. Preliminary results and perspectives of the use of transposable element insertion sites as markers of genetic differentiation and tools for population genetic studies are discussed. (c) 2005 Elsevier Ltd. All rights reserved.