The Association Between Physical Activity and Subclinical Atherosclerosis
The Association Between Physical Activity and Subclinical Atherosclerosis
复制标题
DOI：
10.1093/aje/kwn350
复制
发表时间：
2009-02-15
影响因子：
5
通讯作者：
Jacobs, David R.
中科院分区：
文献类型：
--
作者：
Bertoni, Alain G.;Whitt-Glover, Melicia C.;Jacobs, David R.
先前关于体力活动与亚临床心血管疾病之间关系的报道并不一致。作者通过问卷调查对参与 2000 年至 2002 年动脉粥样硬化多种族研究的 6,482 名年龄 45-84 岁、无临床心血管疾病史的美国成年人进行了身体活动和步行速度评估。测量了踝肱指数 (ABI)、冠状动脉钙化以及颈内动脉和颈总动脉内膜中层厚度 (IMT)。计算每周体力活动的代谢当量小时数。这些数据是通过在特定性别阶层中使用多变量线性或相对患病率回归进行分析的。调整年龄、种族/族裔、诊所地点、教育程度、收入和吸烟情况（模型 1）后，无论性别，增加总量、中等+剧烈和有意运动的体力活动均与 IMT 或冠状动脉钙化无关。这些因素仅与女性 ABI 增加相关（P < 0.05）。调整模型 1 变量后，步行速度与男性颈总动脉 IMT、ABI 和冠状动脉钙化呈正相关，与女性颈总动脉 IMT 和 ABI 呈正相关（所有 P < 0.05）。当将血脂、高血压、糖尿病和体重指数添加到模型中时，这些关联性会减弱，并且对于颈总动脉 IMT 而言不再显着。这些数据表明步行速度与较少的亚临床动脉粥样硬化有关。这些关联可能是由心血管疾病危险因素介导的。
Prior reports regarding the association between physical activity and subclinical cardiovascular disease have not been consistent. The authors assessed physical activity and walking pace via questionnaire among 6,482 US adults aged 45-84 years without prior clinical cardiovascular disease participating in the Multi-Ethnic Study of Atherosclerosis from 2000 to 2002. Ankle-brachial index (ABI), coronary artery calcification, and internal and common carotid intima-media thickness (IMT) were measured. Metabolic equivalent-hours/week of physical activity were calculated. These data were analyzed by using multivariable linear or relative prevalence regression in gender-specific strata. After adjustment for age, race/ethnicity, clinic site, education, income, and smoking (model 1), increasing total, moderate + vigorous, and intentional-exercise physical activity were not associated with IMT or coronary artery calcification in either gender. These factors were associated with increased ABI (P < 0.05) in women only. Walking pace was associated favorably with common carotid IMT, ABI, and coronary artery calcification in men and with common carotid IMT and ABI in women (all P < 0.05) after adjustment for model 1 variables. These associations were attenuated and, for common carotid IMT, no longer significant when lipids, hypertension, diabetes, and body mass index were added to the model. These data suggest that walking pace is associated with less subclinical atherosclerosis; these associations may be mediated by cardiovascular disease risk factors.