Solid breast masses diagnosed as fibroadenoma at fine-needle aspiration biopsy: Acceptable rates of growth at long-term follow-up
Solid breast masses diagnosed as fibroadenoma at fine-needle aspiration biopsy: Acceptable rates of growth at long-term follow-up
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DOI：
10.1148/radiol.2291010282
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发表时间：
2003-10-01
期刊：
影响因子：
19.7
通讯作者：
Lanzkowsky, L
中科院分区：
文献类型：
--
作者：
Gordon, PB;Gagnon, FA;Lanzkowsky, L
目得：为了确定什么样的增长率是可以接受的，然后建议组织学诊断的固体乳腺病变诊断为纤维腺瘤在细针穿刺活检（FNAB）。材料和方法：对于1,070例连续的乳腺病变诊断为纤维腺瘤在FNAB，三个测量每个肿块进行首次访问时，FNAB进行，并在每次随访超声检查。计算体积变化。在一次或多次走访中，有194名群众出现数量增加。排除非纤维腺瘤，数据用于比较。百分位（第90和95次）的每月体积变化百分比用于确定尺寸的可接受变化（具体而言，最大前后、平行于皮肤和平行于皮肤的尺寸）。年龄小于50岁的173例患者的179个肿块进行了567次间隔测量，年龄大于或等于50岁的14例患者的15个肿块进行了50次间隔测量。FNAB的时间对于50岁以下的患者，每月体积变化百分比的第95百分位数约为16%;对于50岁或以上的患者，第90百分位数约为13%。对于50岁以下的受试者，6个月间隔内第95百分位数的平均尺寸变化为20%;对于50岁或以上的受试者，第90百分位数的变化也为20%。所有切除肿块生长缓慢证明良性组织学检查。结论：固体乳腺肿块诊断为纤维腺瘤在FNAB可以安全地随访，如果体积增长率小于16%，每月在那些年轻的50岁，小于13%，每月在那些50岁或以上。对于所有年龄段，6个月间隔内尺寸的可接受平均变化为20%。(C)RSNA，2003年。
PURPOSE: To determine what growth rate is acceptable before recommending histologic diagnosis of solid breast lesions diagnosed as fibroadenoma at fine-needle aspiration biopsy (FNAB).MATERIALS AND METHODS: For 1,070 consecutive patients with breast lesions diagnosed as fibroadenoma at FNAB, three measurements of each mass were performed at the initial visit when FNAB was performed and at each follow-up ultrasonographic examination. Changes in volumes were calculated. At one or more visits, 194 masses showed an increase in volume. Nonfibroadenomas were excluded, and the data were used for comparison. Percentiles (90th and 95th) for percentage change in volume per month were used to determine acceptable changes in dimensions (specifically, greatest anteroposterior, parallel-to-skin, and perpendicular-to-skin dimensions).RESULTS: There were 567 interval measurements of 179 masses in 173 patients younger than 50 years and 50 measurements of 15 masses in 14 patients 50 years or older at the time of FNAB. The 95th percentile for percentage change in volume per month was approximately 16% for patients younger than 50 years; the 90th percentile was approximately 13% for patients 50 years or older. The 95th percentile mean change in dimension in a 6-month interval for those younger than 50 years was 20%; the 90th percentile change for those 50 years or older was also 20%. All excised masses with slower growth proved benign at histologic examination.CONCLUSION: Solid breast masses diagnosed as fibroadenomas at FNAB may be safely followed up if volume growth rate is less than 16% per month in those younger than 50 years and less than 13% per month in those 50 years or older. Acceptable mean change in dimension for a 6-month interval is 20% for all ages. (C) RSNA, 2003.