The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights.
The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights.
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DOI：
10.1016/j.mce.2010.04.005
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发表时间：
2011-03-15
影响因子：
4.1
通讯作者：
Chapman, Karen E.
中科院分区：
文献类型：
--
作者：
Coutinho, Agnes E.;Chapman, Karen E.
自从20世纪40年代发现糖皮质激素并认识到其抗炎作用以来，它们一直是控制炎症和自身免疫性疾病的最广泛使用和最有效的治疗方法之一。然而，其临床疗效受到长期治疗的代谢效应的影响，包括骨质疏松症、高血压、血脂异常和胰岛素抵抗/2型糖尿病。近年来，已经投入了大量的努力来鉴定将糖皮质激素的有益抗炎作用与不良代谢作用分开的化合物，其效果有限。很明显，这些努力是有效的，需要更好地了解糖皮质激素发挥其抗炎和免疫抑制作用的机制。最近的研究对其中一些机制有了新的认识，并产生了一些令人惊讶的新发现。这里对其中一些最近的发展进行了审查。
Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-inflammatory effects, they have been amongst the most widely used and effective treatments to control inflammatory and autoimmune diseases. However, their clinical efficacy is compromised by the metabolic effects of long-term treatment, which include osteoporosis, hypertension, dyslipidaemia and insulin resistance/type 2 diabetes mellitus. In recent years, a great deal of effort has been invested in identifying compounds that separate the beneficial anti-inflammatory effects from the adverse metabolic effects of glucocorticoids, with limited effect. It is clear that for these efforts to be effective, a greater understanding is required of the mechanisms by which glucocorticoids exert their anti-inflammatory and immunosuppressive actions. Recent research is shedding new light on some of these mechanisms and has produced some surprising new findings. Some of these recent developments are reviewed here.
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DOI：
10.1080/10253890802506409
发表时间：
2009-05
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Biddie SC;Hager GL
通讯作者：
Hager GL
影响因子：
20.3
作者：
Bhattacharyya, Sandip;Brown, Diane E.;Muglia, Louis J.
通讯作者：
Muglia, Louis J.
DOI：
10.1196/annals.1366.030
发表时间：
2006-01-01
期刊：
NEUROENDOCRINE AND IMMUNE CROSSTALK
影响因子：
--
作者：
Chapman, Karen E.;Coutinho, Agnes;Seckl, Jonathan R.
通讯作者：
Seckl, Jonathan R.
影响因子：
20.3
作者：
Cannarile, L;Fallarino, F;Riccardi, C
通讯作者：
Riccardi, C
影响因子：
56.9
作者：
AUPHAN, N;DIDONATO, JA;KARIN, M
通讯作者：
KARIN, M