Recruitment techniques for alcohol pharmacotherapy clinical trials: A cost-benefit analysis.
Recruitment techniques for alcohol pharmacotherapy clinical trials: A cost-benefit analysis.
复制标题
酒精药物治疗临床试验的招募技术：成本效益分析。
DOI：
10.1097/adt.0000000000000047
复制
发表时间：
2015
影响因子：
1.1
通讯作者：
Strain,EricC
中科院分区：
文献类型：
--
作者：
Tompkins,DAndrew;Sides,JessicaA;Harrison,JosephA;Strain,EricC
目的：酒精使用障碍(AUDS)是一个巨大的公共健康负担，有效的药物治疗相对较少。新的AUD疗法的随机对照试验(RCT)可能会受到无效招募的阻碍，导致试验成本增加。目前的分析检查了2009至2012年间进行的连续2次AUD新药疗法门诊随机对照试验中招募工作的有效性。方法：在最初的电话筛选中，参与者确定了了解该研究的广告来源。然后，对符合条件的人员进行面对面筛查(IPS)。本分析考察了所使用的8个广告来源之间的人口统计学差异。招聘有效性是通过将符合IPS标准的人数除以每个广告来源的来电者总数来确定的。成本效益通过将总广告源成本除以屏幕数量、随机参与者和完成数来确定。结果：总共1813个电话导致1005个完整的电话屏幕。最常见的广告来源是电视(34%)，其次是平面广告(29%)、口碑(11%)、传单(8%)、互联网(5%)、广播(5%)、公共汽车广告(2%)和广告牌(1%)。报告公交车广告(46%)、广告牌广告(44%)或平面广告(34%)的参与者比其他来源更有可能满足IPSS预定的标准。最具成本效益的广告来源是平面广告(每个完成者2506美元)，而巴士广告最不具成本效益(每个完成者13376美元)。结论：采用多种广告方式可以成功地在澳大利亚RCT招聘。目前的分析认为，使用平面广告是最具成本效益的。
Objectives:Alcohol-use disorders (AUDs) represent a large public health burden with relatively few efficacious pharmacotherapies. Randomized controlled trials (RCTs) for new AUD therapies can be hampered by ineffective recruitment, leading to increased trial costs. The current analyses examined the effectiveness of recruitment efforts during 2 consecutive outpatient RCTs of novel AUD pharmacotherapies conducted between 2009 and 2012.Methods:During an initial phone screen, participants identified an ad source for learning about the study. Qualified persons were then scheduled for in-person screens (IPSs). The present analyses examined demographic differences among the 8 ad sources utilized. Recruitment effectiveness was determined by dividing the number of persons meeting criteria for an IPS by the total number of callers from each ad source. Cost-effectiveness was determined by dividing total ad source cost by number of screens, participants randomized, and completers.Results:A total of 1813 calls resulted in 1005 completed phone screens. The most common ad source was television (34%), followed by print (29%), word-of-mouth (11%), flyer (8%), internet (5%), radio (5%), bus ad (2%), and billboard (1%). Participants reporting bus ads (46%), billboard (44%), or print ads (34%) were significantly more likely than the other sources to meet criteria to be scheduled for IPSs. The most cost-effective ad source was print ($2506 per completer), whereas bus ad was the least cost-effective ($13,376 per completer).Conclusions:Recruitment in AUD RCTs can be successful using diverse advertising methods. The present analyses favored use of print ads as most cost-effective.