The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain
The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain
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DOI：
10.1002/anie.201000620
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发表时间：
2010-01-01
影响因子：
16.6
通讯作者：
Craik, David J.
中科院分区：
文献类型：
--
作者：
Clark, Richard J.;Jensen, Jonas;Craik, David J.
从杀手到治愈者：来自锥螺毒液的肽是治疗神经性疼痛的潜在治疗剂。不幸的是，这些肽具有生物半衰期短和口服时活性差的缺点。开发了一种新的口服活性芋螺毒素来解决这些问题。© 2010 Wiley-VCH Verlag GmbH & Co. KGaA，魏因海姆。
From killers to curers: Peptides from cone snail venoms are potential therapeutic agents for the treatment of neuropathic pain. Unfortunately, these peptides suffer from the disadvantage of short biological half-lives and poor activity when taken orally. A new orally active conotoxin was developed to solve these problems.© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.