Integration of the centrosome in cell cycle control, stress response and signal transduction pathways
Integration of the centrosome in cell cycle control, stress response and signal transduction pathways
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DOI：
10.1016/s0955-0674(01)00291-5
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发表时间：
2002-02-01
影响因子：
7.5
通讯作者：
Lange, BMH
中科院分区：
文献类型：
--
作者：
Lange, BMH
对中心体上细胞周期控制和信号转导成分的鉴定，促进了中心体不仅仅是微管组织中心的想法。事实上，最近的分子证据表明，中心体不仅在微管成核活性的调节中起着积极的作用，而且在中心体复制与细胞周期进程的协调中，在应激反应和细胞周期检查点控制中也起着积极的作用。为了实现这些作用，它与许多信号转导分子相互作用。相互作用的特异性是通过锚定蛋白介导的，锚定蛋白使中心体组分和调节蛋白紧密接近。因此，中心体的分子组成和组织反映了它的多种功能。
The identification of cell cycle control and signal transduction components on the centrosome has fostered the idea that the centrosome is more than a microtubule-organizing center. Indeed, recent molecular evidence suggests that the centrosome plays an active role not only in the regulation of microtubule nucleation activity, but also in the coordination of centrosome duplication with cell cycle progression, in stress response and in cell cycle checkpoint control. To achieve these roles, it interacts with a multitude of signal transduction molecules. The specificity of the interactions is mediated through anchoring proteins that bring centrosomal components and regulatory proteins into close proximity. The molecular composition and organization of the centrosome thus reflects its multiple functions.