Oat‐cell carcinoma of the lung. Its origin and relationship to bronchial carcinoid
Oat‐cell carcinoma of the lung. Its origin and relationship to bronchial carcinoid
复制标题
肺燕麦细胞癌的起源及其与支气管类癌的关系。
作者：
K. Bensch;B. Corrin;R. Pariente;H. Spencer
对正常的支气管上皮和粘液腺进行了电子显微镜检查，发现在肠道内存在与Kultschitzky(亲银)细胞相似的细胞。这些细胞具有较长的细胞质突起，少量存在于支气管树的各级，并与基底膜相邻。它们含有被称为神经分泌型颗粒的特征细胞质颗粒，类似于肠嗜银细胞、肾上腺髓质细胞和交感神经末梢中存在的颗粒。18例支气管类癌和22例燕麦细胞肺癌也被发现在肿瘤细胞质中含有类似的神经分泌型颗粒。根据燕麦细胞肺癌与支气管类癌在光镜下的相似性以及产生相似的常见激素紊乱模式和具有相似的超微结构特征，提示燕麦细胞肺癌与支气管类癌密切相关。它们可能分别是来自Kultschitzky细胞的恶性和局部恶性形式的肿瘤，这些细胞通常在整个支气管树上都能发现。
Electron‐microscopic examination of normal bronchial epithelium and mucous glands has revealed the presence of cells similar in appearance to Kultschitzky (argentaffin) cells in the intestinal canal. The cells, which possess long cytoplasmic processes, are present in small numbers at all levels of the bronchial tree and are found adjacent to the basement membrane. They contain characteristic cytoplasmic granules referred to as neurosecretory‐type granules, which are similar to those present in intestinal argentaffin cells, adrenal medullary cells and sympathetic nerve endings. Eighteen bronchial carcinoid tumors and 22 oat‐cell pulmonary cancers have also been found to contain similar neurosecretory‐type granules in the tumor cell cytoplasm. On the basis of light‐microscopic similarities and the production of similar common patterns of hormonal disturbances and the possession of similar ultramicroscopic features, it is suggested that oat‐cell pulmonary cancer and bronchial carcinoid tumors are closely related. They may be, respectively, the malignant and locally malignant form of tumors derived from Kultschitzky‐type cells normally found throughout the bronchial tree.