Adjuvant-induced polyarthritis. Synovial cell activation prior to polyarthritis onset.
Adjuvant-induced polyarthritis. Synovial cell activation prior to polyarthritis onset.
复制标题
佐剂诱发的多关节炎。
作者：
J. López‐Bote;C. Bernabéu;A. Marquet;J. Fernández;V. Larraga
我们研究了滑膜细胞从大鼠已注射弗氏完全佐剂12天前杀死。我们发现，在这些滑膜细胞，即伴刀豆球蛋白A蛋白结合模式，超氧化物的生产，和外观的p77多肽，这是我们以前已经证明与激活引起的诱导多发性关节炎的激活参数受到影响。我们的研究结果表明，在炎症过程建立之前，滑膜细胞处于激活状态，并且可能是疾病早期分子机制的组成部分。
We studied synoviocytes obtained from rats that had been injected with Freund's complete adjuvant 12 days prior to killing. We found that several activation parameters were affected in these synoviocytes, namely, the concanavalin A protein-binding pattern, the production of superoxide, and the appearance of the p77 polypeptide, which we have previously shown to be associated with the activation caused by the induction of polyarthritis. Our findings suggest that prior to the establishment of the inflammatory process, synoviocytes are in a state of activation, and may be a component of the molecular mechanism during the early stages of disease.
小鼠腹腔巨噬细胞的激活改变了蛋白质结合的乳糖胺聚糖的结构和表面表达。
DOI：
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发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Mercurio,AM;Robbins,PW
通讯作者：
Robbins,PW
II 型胶原诱导小鼠关节炎。
DOI：
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发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Wooley,PH;Luthra,HS;Lafuse,WP;Huse,A;Stuart,JM;David,CS
通讯作者：
David,CS