A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice
A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice
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DOI：
10.1016/j.ijcard.2015.06.136
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发表时间：
2015-11-01
影响因子：
3.5
通讯作者：
Toldo, Stefano
中科院分区：
文献类型：
--
作者：
Carbone, Salvatore;Mauro, Adolfo G.;Toldo, Stefano
【摘要】：背景:心力衰竭(heart failure,HF)是一种以呼吸困难、疲劳、运动不耐受和心功能不全为特征的临床综合征。不健康的饮食与肥胖和心脏病的风险增加有关，但它是否直接影响心脏功能，促进心力衰竭的发生和进展尚不清楚。 方法：用标准饮食（SD）或富含饱和脂肪和糖的饮食（类似于“西方”饮食（WD））喂养8周龄的雄性或雌性CD-1小鼠。在基线以及第4周和第8周时通过多普勒超声心动图测量心脏收缩和舒张功能，并在处死前通过心导管插入术测量左心室（LV）舒张末压（EDP）。另外一组小鼠接受 WD 4 周，然后接受 SD（冲洗）8 周。结果：WD 喂养的小鼠左室射血分数 (LVEF) 显着降低，反映收缩功能受损，而等容舒张时间 (IRT)、心肌性能指数 (MPI) 和 LVEDP 显着增加，显示舒张功能受损，但没有任何性别相关的差异。 WD 4 周后改用 SD 部分逆转了心脏收缩和舒张功能障碍。结论：富含饱和脂肪和糖 (WD) 的饮食会损害小鼠的心脏收缩和舒张功能。需要进一步的研究来明确饮食影响心脏功能的机制，以及饮食干预是否可以用于心力衰竭或有心力衰竭风险的患者。由爱思唯尔爱尔兰有限公司出版
Background: Heart failure (HF) is a clinical syndrome characterized by dyspnea, fatigue, exercise intolerance and cardiac dysfunction. Unhealthy diet has been associated with increased risk of obesity and heart disease, but whether it directly affects cardiac function, and promotes the development and progression of HF is unknown.Methods: Wefed 8-week old male or female CD-1 mice with a standard diet (SD) or a diet rich in saturated fat and sugar, resembling a "Western" diet (WD). Cardiac systolic and diastolic function was measured at baseline and 4 and 8 weeks by Doppler echocardiography, and left ventricular (LV) end-diastolic pressure (EDP) by cardiac catheterization prior to sacrifice. An additional group of mice received WD for 4 weeks followed by SD (washout) for 8 weeks.Results: WD-fed mice experienced a significant decreased in LV ejection fraction (LVEF), reflecting impaired systolic function, and a significant increase in isovolumetric relaxation time (IRT), myocardial performance index (MPI), and LVEDP, showing impaired diastolic function, without any sex-related differences. Switching to a SD after 4 weeks of WD partially reversed the cardiac systolic and diastolic dysfunction.Conclusions: A diet rich in saturated fat and sugars (WD) impairs cardiac systolic and diastolic function in the mouse. Further studies are required to define the mechanism through which diet affects cardiac function, and whether dietary interventions can be used in patients with, or at risk for, HF. Published by Elsevier Ireland Ltd.