Cancer and Thrombotic Risk: The Platelet Paradigm.

Cancer and Thrombotic Risk: The Platelet Paradigm.
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DOI:
10.3389/fcvm.2017.00067
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发表时间:
2017
影响因子:
3.6
通讯作者:
Cameron SJ
Cameron SJ
中科院分区:
医学3区
文献类型:
--
作者:
Lee EC;Cameron SJ

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血液恶性肿瘤和实体瘤增加了静脉和动脉血栓形成的风险,并极大地增加了患者的发病率和死亡率。当循环抗血栓和促血栓血液元素的复杂平衡被破坏时,就会发生血栓形成。近年来,副肿瘤细胞和血小板之间的相互作用变得明显,血小板表型的变化引起血小板活性失调。这篇综述讨论了癌症血栓形成的机制,使用药物治疗的证据,以及令人兴奋的研究工作,以了解并希望控制癌症患者的异常血栓形成事件。
Hematologic malignancies and solid tumors increase the risk of venous and arterial thrombosis and contribute greatly to patient morbidity and mortality. Thrombosis occurs when the intricate balance of circulating antithrombotic and prothrombotic blood elements are disrupted. In recent years, the interplay between paraneoplastic cells and platelets has become apparent, with a change in platelet phenotype causing dysregulated platelet activity. This review discusses mechanism of thrombosis in cancer, evidence for using drug therapy, and exciting research efforts to understand and hopefully control aberrant thrombotic events in patients with cancer.
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