Cancer and Thrombotic Risk: The Platelet Paradigm.
Cancer and Thrombotic Risk: The Platelet Paradigm.
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DOI:
10.3389/fcvm.2017.00067
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发表时间:
2017
影响因子:
3.6
通讯作者:
Cameron SJ
中科院分区:
文献类型:
--
作者:
Lee EC;Cameron SJ
Hematologic malignancies and solid tumors increase the risk of venous and arterial thrombosis and contribute greatly to patient morbidity and mortality. Thrombosis occurs when the intricate balance of circulating antithrombotic and prothrombotic blood elements are disrupted. In recent years, the interplay between paraneoplastic cells and platelets has become apparent, with a change in platelet phenotype causing dysregulated platelet activity. This review discusses mechanism of thrombosis in cancer, evidence for using drug therapy, and exciting research efforts to understand and hopefully control aberrant thrombotic events in patients with cancer.
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DOI:
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