Development, maturation and growth of the myodural bridge within the posterior atlanto‐axial interspace in the rat
Development, maturation and growth of the myodural bridge within the posterior atlanto‐axial interspace in the rat
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大鼠寰枢椎后间隙内肌硬膜桥的发育、成熟和生长
DOI：
10.1002/jmor.21467
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发表时间：
2022
影响因子：
1.5
通讯作者：
Hong‐jin Sui
中科院分区：
文献类型：
--
作者：
Hua-Xun Lai;Jin Gong;Gary D. Hack;Ting‐wei Song;Bo Liu;Sheng‐bo Yu;Jian‐fei Zhang;Hong‐jin Sui
肌硬膜桥（MDB）复合体是功能性地将脊髓硬膜与枕下肌肉组织连接起来的纤维桥。此前，我们描述了大鼠寰枕后间隙内MDB的成熟过程。本文描述了大鼠寰枢后间隙内MDB的形态和发育成熟情况。在本研究中，选取了胚胎第18天的大鼠、新生大鼠和成年大鼠来评估MDB的发育和生长情况。在大鼠寰枢后间隙内，胚胎大鼠的MDB纤维及其相关肌肉稀少且染色较浅。相比之下，在新生大鼠中观察到的这些相同结构则非常明显且染色深。出生后，观察到MDB起源于头后大直肌，向前向下延伸，最终与寰枢后膜融合。随着大鼠的发育和成熟，观察到穿过寰枢后间隙的MDB纤维变得更密集且更有序。本研究证明，新生大鼠寰枢后间隙内的MDB纤维主要由I型胶原纤维组成。通过观察枕下区域，我们可以假设MDB复合体在生长发育过程中对维持上颈椎节段内的硬膜下间隙起着关键作用。本研究为未来MDB复合体功能的研究提供了形态学基础。
The myodural bridge (MDB) complex are fibrous bridges that functionally connect the spinal dura mater to the suboccipital musculature. Previously, we described the maturational sequence of the MDB within the posterior atlanto-occipital interspace of the rat. The present paper describes the morphology and developmental maturation of the MDB within the posterior atlanto-axial interspace of the rat. In the present study, E18 embryonic rats, newborn rats, and adult rats were selected to evaluate the development and growth of the MDB. Within the posterior atlanto-axial interspace of the rat, the fibers of the MDB and its associated muscles, in the embryonic rat, were observed to be scarce and lightly stained. In contrast, these same structures observed in the postnatal rat were quite apparent and robustly stained. After birth, it was observed that MDB originated from the rectus capitis dorsal major muscle, extended forward and downward, and finally merged with the posterior atlanto-axial membrane. As the rats developed and matured, the observed MDB fibers passing through the posterior atlanto-axial interspace appeared denser and more organized. This study evidenced that the MDB fibers within the posterior atlanto-axial interspace were primarily composed of type I collagen fibers in the postnatal rat. By observing the suboccipital region, we are able to hypothesize that the MDB complex plays a key role in maintaining the subdural space located within the upper cervical segment during growth and development. This study provides a morphological basis for future research on the function of the MDB complex.