Microstructural proliferation in human cortex is coupled with the development of face processing.
Microstructural proliferation in human cortex is coupled with the development of face processing.
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DOI：
10.1126/science.aag0311
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发表时间：
2017-01-06
期刊：
影响因子：
--
通讯作者：
Grill-Spector K
中科院分区：
文献类型：
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作者：
Gomez J;Barnett MA;Natu V;Mezer A;Palomero-Gallagher N;Weiner KS;Amunts K;Zilles K;Grill-Spector K
从童年到成年，随着大脑功能和行为的改善，皮质组织是如何变化的？通过结合儿童和成人的定量和功能磁共振成像，我们发现了参与面部和位置识别的高级视觉区域的差异发展。发展面选择性区域，但不是位置选择性区域，是由微观结构的扩散。这种组织发育与特定的面部功能选择性的增加以及面部识别的改善相关，并最终导致成年期面部和位置选择性区域之间的差异化组织特性，我们用死后细胞结构测量进行了验证。这些数据提出了一种新的模型，即大脑功能和行为的产生是由于皮层组织的增殖，而不是仅仅由于修剪。
How does cortical tissue change as brain function and behavior improve from childhood to adulthood? By combining quantitative and functional magnetic resonance imaging in children and adults, we find differential development of high-level visual areas that are involved in face and place recognition. Development of face-selective regions, but not place-selective regions, is dominated by microstructural proliferation. This tissue development is correlated with specific increases in functional selectivity to faces, as well as improvements in face recognition, and ultimately leads to differentiated tissue properties between face-and place-selective regions in adulthood, which we validate with postmortem cytoarchitectonic measurements. These data suggest a new model by which emergent brain function and behavior result from cortical tissue proliferation rather than from pruning exclusively.