The influence of aging on plasma sex hormones in men: the Telecom Study.
The influence of aging on plasma sex hormones in men: the Telecom Study.
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衰老对男性血浆性激素的影响：电信研究。
DOI：
10.1093/oxfordjournals.aje.a116365
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发表时间：
1992
影响因子：
5
通讯作者：
L. Papoz
中科院分区：
文献类型：
--
作者：
Dominique Simon;P. Preziosi;E. Barrett;M. Roger;Michel Saint;K. Nahoul;L. Papoz
从1985年4月至1987年7月，在法国巴黎招募了1，408名20-60岁的健康白色男性，在一项横断面研究中进行了体格检查和血浆性激素测量。总睾酮和雌二醇显示出显着的逐步下降，随着年龄的增长（p <0.001）开始在成年早期，而雌酮没有变化。这些睾酮和雌二醇与年龄的关系仍然显着调整后的体重指数，肩胛下皮褶，烟草和酒精的消费，他们没有修改的男性谁报告的慢性疾病排除。早期睾酮下降的机制及其临床意义值得进一步研究。
From April 1985 to July 1987, 1,408 healthy white men aged 20-60 years in Paris, France, recruited on an occupational basis, underwent a physical examination and measurements of plasma sex hormones in a cross-sectional study. Both total testosterone and estradiol showed a significant stepwise decrease with age (p less than 0.001) starting in the early adult years, while estrone did not vary. These relations of testosterone and estradiol with age remained significant after adjustment for body mass index, subscapular skinfold, and tobacco and alcohol consumptions, and they were not modified by exclusion of the men who reported chronic disease. Both the mechanism for the early decrease in testosterone and its clinical significance merit further investigation.