Postoperative decrease in plasma acyl ghrelin levels after pediatric living donor liver transplantation in association with hepatic damage due to ischemia and reperfusion injury
Postoperative decrease in plasma acyl ghrelin levels after pediatric living donor liver transplantation in association with hepatic damage due to ischemia and reperfusion injury
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DOI：
10.1007/s00383-019-04463-8
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发表时间：
2019-03
影响因子：
1.8
通讯作者：
Masahiro Zenitani;H. Hosoda;T. Kodama;R. Saka;Y. Takama;T. Ueno;Y. Tazuke;K. Kangawa;T. Oue;H. Okuyama
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文献类型：
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作者：
Masahiro Zenitani;H. Hosoda;T. Kodama;R. Saka;Y. Takama;T. Ueno;Y. Tazuke;K. Kangawa;T. Oue;H. Okuyama
目的Ghrelin具有促进肝损伤后恢复的作用。我们推测这也可能与移植肝脏缺血再灌注损伤的临床恢复有关。我们的目的是调查围手术期ghrelin的变化后，小儿活体肝移植（LDLT），并分析这些变化与术后hepatocellularfunction.MethodsWe测定血浆酰基ghrelin（AG）浓度术前，在手术结束时，并在术后第1天（PODs），3和7 12名儿童谁经历了LDLT，并作为对照，7例接受良性腹部肿块切除术的儿童的术前、术后和术后第1天。参与者的ghrelin配置文件和肝功能相关data.ResultsAG水平显着下降到15.6%的术前水平LDLT后，几乎恢复到基线POD 3之间的相关性进行了评估。术后AG水平显着降低到更大程度后LDLT比良性腹部肿块切除术。POD 1时AG水平与AST水平及冷/总缺血时间呈负相关（P<0.0 5）。结论POD 1时AG水平降低可能反映了移植肝缺血再灌注损伤的程度。
PurposeGhrelin was recently reported to promote recovery from hepatic injury. We hypothesized that it could also be associated with clinical recovery of the transplanted liver from ischemia and reperfusion injury. Our aims were to investigate perioperative ghrelin changes following pediatric living donor liver transplantation (LDLT) and to analyze the association of these changes with postoperative hepatic function.MethodsWe measured plasma acyl ghrelin (AG) concentrations before surgery, at the end of surgery and on postoperative days (PODs) 1, 3 and 7 in 12 children who underwent LDLTs, and, as controls, pre- and post-operatively and on POD1 in 7 children who underwent benign abdominal mass resection. The correlations between the participants’ ghrelin profiles and hepatic function-related data were evaluated.ResultsAG levels significantly declined to 15.6% of preoperative levels after LDLT and almost returned to baseline on POD3. Post-operative AG levels were significantly reduced to a greater extent following LDLT than benign abdominal mass resection. AG levels on POD1 inversely correlated with aspartate aminotransferase levels and cold/total ischemia time (P< 0.05).ConclusionThese results suggest that reduced AG levels on POD1 may reflect the degree of damage to the transplanted liver due to ischemia and reperfusion injury.