Respiratory cryptosporidiosis in HIV-seronegative children in Uganda: potential for respiratory transmission.
Respiratory cryptosporidiosis in HIV-seronegative children in Uganda: potential for respiratory transmission.
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DOI：
10.1086/652140
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发表时间：
2010-05-15
期刊：
影响因子：
--
通讯作者：
Griffiths JK
中科院分区：
文献类型：
--
作者：
Mor SM;Tumwine JK;Ndeezi G;Srinivasan MG;Kaddu-Mulindwa DH;Tzipori S;Griffiths JK
Respiratory cryptosporidiosis is recognized as a late-stage complication in persons with HIV/AIDS. However, respiratory signs and symptoms are common in otherwise healthy children with intestinal cryptosporidiosis, suggesting that respiratory infection may occur in immunocompetent hosts. We recruited children aged 9–36 months who presented with diarrhea to Mulago Hospital in Kampala, Uganda. Children with Cryptosporidium-positive and -negative stools were selected for further evaluation, including sputum induction in those with cough or unexplained respiratory signs, and collection of saliva and blood. Sputum samples were subjected to comprehensive bacteriological testing, and both sputum and saliva were tested for Cryptosporidium by nested-PCR. Of 926 fecal samples screened, 116 (12.5%) were Cryptosporidium positive. Seventeen of 48 (35.4%) sputum samples tested from stool-positive children were positive for Cryptosporidium. Sixteen of the 17 children with confirmed respiratory cryptosporidiosis were HIV-seronegative and 10/17 (58.8%) children were normally nourished. None of the 12 sputum specimens tested from stool-negative children were Cryptosporidium positive (p=0.013 compared to stool-positive children). Parasite DNA was only detected in 2/103 (1.9%) saliva samples (p<0.0001 compared to sputum). Respiratory cryptosporidiosis was documented in one third of HIV-seronegative children who were tested. These novel findings suggest the potential for respiratory transmission. This study is registered with ClinicalTrials.gov, number NCT00507871.
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DOI：
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发表时间：
2005-11-01
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作者：
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