TRIM Proteins and Their Roles in Antiviral Host Defenses.
TRIM Proteins and Their Roles in Antiviral Host Defenses.
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DOI：
10.1146/annurev-virology-092917-043323
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发表时间：
2018-09-29
影响因子：
11.3
通讯作者：
Gack MU
中科院分区：
文献类型：
--
作者：
van Gent M;Sparrer KMJ;Gack MU
Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a multitude of cellular processes. Studies in recent years have demonstrated that many TRIM proteins play central roles in the host defense against viral infection. While some TRIM proteins directly antagonize distinct steps in the viral life cycle, others regulate signal transduction pathways induced by innate immune sensors, thereby modulating antiviral cytokine responses. Furthermore, TRIM proteins have been implicated in virus-induced autophagy and autophagy-mediated viral clearance. Given the important role of TRIM proteins in antiviral restriction, it is not surprising that several viruses have evolved effective maneuvers to neutralize the antiviral action of specific TRIM proteins. Here, we describe the major antiviral mechanisms of TRIM proteins as well as viral strategies to escape TRIM-mediated host immunity.
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影响因子：
30.5
作者：
Chiang JJ;Sparrer KMJ;van Gent M;Lässig C;Huang T;Osterrieder N;Hopfner KP;Gack MU
通讯作者：
Gack MU
影响因子：
6.7
作者：
Barr SD;Smiley JR;Bushman FD
通讯作者：
Bushman FD
影响因子：
5.4
作者：
Chelbi-Alix, MK;Quignon, F;De Thé, H
通讯作者：
De Thé, H
影响因子：
64.5
作者：
Edwards, TA;Pyle, SE;Aggarwal, AK
通讯作者：
Aggarwal, AK
影响因子：
5.4
作者：
Castanier C;Zemirli N;Portier A;Garcin D;Bidère N;Vazquez A;Arnoult D
通讯作者：
Arnoult D