Assessment of the Cadmium Exposure in the Blood, Diet, and Water of the Pumi People in Yunnan, China
Assessment of the Cadmium Exposure in the Blood, Diet, and Water of the Pumi People in Yunnan, China
复制标题
中国云南普米族血液、饮食和水中镉暴露评估
DOI：
10.1007/s12011-015-0452-y
复制
发表时间：
2015-12-01
影响因子：
3.9
通讯作者：
Yang, Ya-Ling
中科院分区：
文献类型：
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作者：
Wang, Qi;Feng, Yue-Mei;Yang, Ya-Ling
镉（Cd）被认为是毒性最大、致癌性最强的重金属之一。镉在人体内蓄积可引起多器官功能障碍。长期不合理的采矿活动导致土壤、水体乃至农产品中镉污染严重。因此，评价矿区居民镉暴露水平具有重要意义。本研究选择云南省兰坪县金顶镇和铜店镇的普米族居民进行现场营养流行病学调查和实验室检测。我们分析了两个镇普米族居民的外周血和混合膳食以及水样中镉的含量。结果表明，距矿区较近的金顶镇居民血镉水平明显高于同店镇居民血镉水平。两镇血镉P_（50）值均为0.64 ng/mL。两镇混合日粮的P_（50）为8.32 μg/kg。普米人的混合饮食、PTDI和PTWI中，血镉水平与镉暴露之间存在弱相关性。此外，金顶镇水体中Cd浓度较高，表明金顶镇居民存在较高的Cd暴露风险。这些结果表明，饮食和水是居民镉暴露的关键因素，越靠近矿区的居民镉暴露风险越大。
Cadmium (Cd) is considered as one of the most toxic and carcinogenic heavy metals. Accumulation of Cd in the human body can cause multiorgan dysfunction. Long-term irrational mining activities have led to serious Cd pollution in soil, water, and even agricultural products. Therefore, evaluating the Cd exposure levels of people living in mining areas is of great importance. In the current study, we chose the Pumi people who lived in Jinding and Tongdian towns of Lanping county in Yunnan province, China, to do the on-site nutritional epidemiology investigation and laboratory detection. We analyzed the content of the Cd in peripheral blood and mixed dietary, as well as water samples in the Pumi residents of the two towns. Results showed that the blood Cd levels of people in Jinding town, which is nearer the mining district, were statistically significantly higher than those in Tongdian town. TheP50of blood Cd level of the two towns was 0.64 ng/mL. In addition, theP50of the mixed diet of the two towns was 8.32 μg/kg. There was a weak correlation between blood Cd levels and Cd exposure in the mixed diet, PTDI, and PTWI of the Pumi people. In addition, higher concentrations of Cd were observed in the water of Jinding town, indicating people in Jinding town risking more Cd exposure. These results indicated that diet and water are critical factors of Cd exposure for the residents and the nearer people living to mining district risking the more Cd exposure.