Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease.
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease.
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DOI：
10.1126/science.1259077
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发表时间：
2014-10-17
期刊：
影响因子：
--
通讯作者：
Sakaguchi S
中科院分区：
文献类型：
--
作者：
Ito Y;Hashimoto M;Hirota K;Ohkura N;Morikawa H;Nishikawa H;Tanaka A;Furu M;Ito H;Fujii T;Nomura T;Yamazaki S;Morita A;Vignali DA;Kappler JW;Matsuda S;Mimori T;Sakaguchi N;Sakaguchi S
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T cells mediating autoimmune diseases, such as rheumatoid arthritis (RA), are difficult to characterize because they are likely to be deleted or inactivated in the thymus if the self-antigens they recognize are ubiquitously expressed. One way to obtain and analyze these autoimmune T cells is to alter T cell receptor (TCR) signaling in developing T cells to change their sensitivity to thymic negative selection, thereby allowing their thymic production. From mice thus engineered to generate T cells mediating autoimmune arthritis, we have isolated arthritogenic TCRs and characterized the self-antigens they recognized. One of them was the ubiquitously expressed 60S ribosomal protein L23a (RPL23A), with which T cells and autoantibodies from RA patients reacted. This strategy may improve our understanding of the underlying drivers of autoimmunity.
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DOI：
10.1084/jem.20082902
发表时间：
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期刊：
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