Psychological Correlates of Self-reported Disease Activity in Ankylosing Spondylitis
Psychological Correlates of Self-reported Disease Activity in Ankylosing Spondylitis
复制标题
DOI：
10.3899/jrheum.090476
复制
发表时间：
2010-04-01
影响因子：
3.9
通讯作者：
Nicassio, Perry
中科院分区：
文献类型：
--
作者：
Brionez, Tamar F.;Assassi, Shervin;Nicassio, Perry
客观的。调查心理变量在强直性脊柱炎 (AS) 患者自我报告疾病活动中的作用，同时控制人口和医学变量。方法。符合修改后的纽约标准的 AS 患者 (n = 294) 完成了评估抑郁、复原力、主动和被动应对、内在性和无助感的心理测量。还收集了人口统计、临床和放射学数据。完成单变量和多变量分析以确定心理变量与疾病活动的相关强度，通过巴斯 AS 疾病活动指数 (BASDAI) 进行测量。结果。在多元回归分析中，心理变量对 BASDAI 分数的方差贡献显着，在人口统计和医学变量的影响之外，为总体 R 方增加了 33%（R 方合计 18%）。具体来说，关节炎无助和抑郁是最终模型中 BASDAI 评分差异的最显着部分。结论。除了临床和人口统计学变量之外，关节炎患者的无助感和抑郁症导致了自我报告的疾病活动的显着变异。这些发现对于 AS 疾病活动的治疗和监测具有重要的临床意义，并提出了潜在的干预途径。 （首次发布，2010 年 2 月 15 日；J Rheumatol 2010；37:829-34；doi:10.3899/jrheum.090476）
Objective. To investigate the role of psychological variables in self-reported disease activity in patients with ankylosing spondylitis (AS), while controlling for demographic and medical variables.Methods. Patients with AS (n = 294) meeting modified New York criteria completed psychological measures evaluating depression, resilience, active and passive coping, internality, and helplessness. Demographic, clinical, and radiologic data were also collected. Univariate and multivariate analyses were completed to determine the strength of the correlation of psychological variables with disease activity, as measured by the Bath AS Disease Activity Index (BASDAI).Results. In the multivariate regression analysis, the psychological variables contributed significantly to the variance in BASDAI scores, adding an additional 33% to the overall R-square beyond that accounted for by demographic and medical variables (combined R-square 18%). Specifically, arthritis helplessness and depression accounted for the most significant portion of the variance in BASDAI scores in the final model.Conclusion. Arthritis helplessness and depression accounted for significant variability in self-reported disease activity beyond clinical and demographic variables in patients with AS. These findings have important clinical implications in the treatment and monitoring of disease activity in AS, and suggest potential avenues of intervention. (First Release Feb 15 2010; J Rheumatol 2010;37:829-34; doi:10.3899/jrheum.090476)