Catalytic asymmetric hydrophosphonylation of ketimines.
Catalytic asymmetric hydrophosphonylation of ketimines.
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DOI：
10.1021/ja4059316
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发表时间：
2013-07
影响因子：
15
通讯作者：
L. Yin;Youmei Bao;N. Kumagai;M. Shibasaki
中科院分区：
文献类型：
--
作者：
L. Yin;Youmei Bao;N. Kumagai;M. Shibasaki
芳香族和脂肪族N-硫代膦酰基酮亚胺与亚磷酸二烷基酯的催化不对称氢膦酰化反应在室温下仅需0.5mol%的催化剂负载量就能有效地促进。该催化剂可以回收重复使用，并且容易除去硫代膦酰基基团，使得容易获得对映体富集的α，α-二取代的α-氨基酸的膦酸类似物。
Catalytic asymmetric hydrophosphonylation of aromatic and aliphatic N-thiophosphinoyl ketimines with dialkyl phosphite was efficiently promoted by as little as 0.5 mol% of catalyst loading at ambient temperature. The catalyst can be recovered for repeated use, and facile removal of the thiophosphinoyl group allowed for ready access to the phosphonic acid analogue of enantioenriched α,α-disubstituted α-amino acids.