VARIABLE EXPRESSION OF VIRULENCE IN THE RODENT MALARIA PARASITE PLASMODIUM-YOELII-YOELII
VARIABLE EXPRESSION OF VIRULENCE IN THE RODENT MALARIA PARASITE PLASMODIUM-YOELII-YOELII
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DOI：
10.1017/s0031182000055165
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发表时间：
1980-01-01
期刊：
影响因子：
2.4
通讯作者：
WALLIKER, D
中科院分区：
文献类型：
--
作者：
KNOWLES, G;WALLIKER, D
研究了约氏假单胞菌毒力系（YM）中毒力特征的表达。通过计数成熟红细胞[小鼠]的寄生虫血症来测量毒力水平。从毒力系 YM 中分离出几个亚克隆，并测试每个亚克隆的毒力水平。 10 个亚克隆中，有 1 个显示出毒力显着下降。该亚克隆通过蚊子的传播完全恢复了其毒力。从轻度和毒力亲本杂交的后代中分离出的克隆具有中等毒力水平。从该中间毒力系中分离出的亚克隆表现出大大降低的毒力。该亚克隆的蚊虫传播也将其毒力恢复到与毒力系YM相当的水平。
The expression of the virulence character in the virulent line (YM) of P. yoelii yoelii was investigated. The level of virulence was measured by counting the parasitemia of mature red blood cells [mouse]. Several sub-clones were isolated from the virulent line YM and each was tested for its level of virulence. Of 10 sub-clones, 1 showed a marked decrease in virulence. Transmission of this sub-clone through mosquitoes fully restored its virulence. A clone isolated from the progency of a cross between mild and virulent parents had an intermediate level of virulence. A sub-clone isolated from this intermediate virulent line exhibited greatly reduced virulence. Mosquito transmission of this sub-clone also restored its virulence to a level comparable with the virulent line YM.