Adenosine 2A receptor agonism: A single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats.
Adenosine 2A receptor agonism: A single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats.
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DOI：
10.1016/j.bbi.2015.01.014
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发表时间：
2015-05
影响因子：
15.1
通讯作者：
Watkins, Linda R.
中科院分区：
文献类型：
--
作者：
Loram, Lisa C.;Strand, Keith A.;Taylor, Frederick R.;Sloane, Evan;Van Dam, Anne-Marie;Rieger, Jayson;Maier, Steven F.;Watkins, Linda R.
A single intrathecal dose of adenosine 2A receptor (A2AR) agonist was previously reported to produce a multi-week reversal of allodynia in two different models of neuropathic pain in addition to downregulating glial activation markers in the spinal cord. We aimed to determine whether a single intrathecal administration of an A2AR agonist was able to attenuate motor symptoms induced by experimental autoimmune encephalopathy. Two A2AR agonists (CGS21680 and ATL313) significantly attenuated progression of motor symptoms following a single intrathecal administration at the onset of motor symptoms. OX-42, a marker of microglial activation, was significantly attenuated in the lumbar spinal cord following A2AR administration compared to vehicle. Therefore, A2AR agonists attenuate motor symptoms of EAE by acting on A2AR in the spinal cord.
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DOI：
10.1523/jneurosci.3447-09.2009
发表时间：
2009-11-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Loram LC;Harrison JA;Sloane EM;Hutchinson MR;Sholar P;Taylor FR;Berkelhammer D;Coats BD;Poole S;Milligan ED;Maier SF;Rieger J;Watkins LR
通讯作者：
Watkins LR
影响因子：
15.1
作者：
Sloane, Evan;Ledeboer, A.;Seibert, W.;Coats, B.;van Strien, M.;Maier, S. F.;Johnson, K. W.;Chavez, R.;Watkins, L. R.;Leinwand, L.;Milligan, E. D.;Van Dam, A. M.
通讯作者：
Van Dam, A. M.
影响因子：
15.1
作者：
Loram, Lisa C.;Taylor, Frederick R.;Strand, Keith A.;Harrison, Jacqueline A.;RzasaLynn, Rachael;Sholar, Paige;Rieger, Jayson;Maier, Steven F.;Watkins, Linda R.
通讯作者：
Watkins, Linda R.
影响因子：
2.9
作者：
Chen, Guo Qian;Chen, Yan Yan;Zheng, Rong Yuan
通讯作者：
Zheng, Rong Yuan
影响因子：
25
作者：
Ajami, Bahareh;Bennett, Jami L.;Rossi, Fabio M. V.
通讯作者：
Rossi, Fabio M. V.