Alendronate and naproxen are synergistic for development of gastric ulcers
Alendronate and naproxen are synergistic for development of gastric ulcers
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DOI：
10.1001/archinte.161.1.107
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发表时间：
2001-01-08
影响因子：
--
通讯作者：
Malaty, HM
中科院分区：
文献类型：
--
作者：
Graham, DY;Malaty, HM
背景：阿仑膦酸钠和非甾体抗炎药的使用都与胃溃疡有关。本研究的目的是探讨是否阿仑膦酸钠和萘普生是协同的原因胃溃疡。方法：我们进行了内镜盲，随机，交叉，单中心比较阿仑膦酸钠10毫克/天，500毫克的萘普生钠每日两次，或口服10天的组合在志愿者年龄30岁或以上。在每次治疗前后，使用视频内窥镜检查评估食管、胃或十二指肠球部粘膜损伤的存在和程度。有一个1至4周之间的洗脱evaluations.Results：26名健康志愿者参加（18名女性和8名男性），年龄30至50岁。阿仑膦酸钠组2例（8%），萘普生组3例（12%），两种治疗组10例（38%）出现胃溃疡（P
Background: Both alendronate sodium use and nonsteroidal anti-inflammatory drug use are associated with gastric ulcers. The aim of this study was to investigate whether alendronate and naproxen are synergistic as causes of gastric ulcers.Methods: We performed an endoscopist-blind, randomized, crossover, single-center comparison of 10 mg/d of alendronate sodium, 500 mg of naproxen sodium twice daily, or the combination taken orally for 10 days in volunteers aged 30 years or older. Videoendoscopy was used to evaluate the presence and degree of mucosal damage to the esophagus, stomach, or duodenal bulb before and after each treatment. There was a 1- to 4-week washout between evaluations.Results: Twenty-six healthy volunteers participated (18 women and 8 men), aged 30 to 50 years. Gastric ulcers were present in 2 subjects receiving alendronate (8%), in 3 receiving naproxen (12%), and in 10 receiving both (38%) (P