Protein kinase C-α and the regulation of diverse cell responses
Protein kinase C-α and the regulation of diverse cell responses
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DOI：
10.1515/bmc-2017-0005
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发表时间：
2017-09-01
影响因子：
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通讯作者：
Acharya, Arbind
中科院分区：
文献类型：
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作者：
Singh, Rishi Kant;Kumar, Sanjay;Acharya, Arbind
蛋白激酶C （PKC）包括一个脂质敏感酶家族，参与了广泛的细胞功能。PKC- α是经典PKC的成员，具有普遍表达和不同的细胞定位。这种独特的PKC异构体被各种引起脂质水解的信号激活，激活后它与各种适配器蛋白相互作用，并定位于特定的细胞区室，在那里它被设计工作。它在各种刺激下的普遍表达和激活，使其在细胞分化、增殖、凋亡、细胞转化、运动、粘附等无数细胞功能中发挥着重要作用。然而，这些功能不是pkc - α的固有特性，而是取决于细胞类型和条件。pkc - α的活性受到各种药理激活剂/抑制剂和反义寡核苷酸的控制。本文旨在阐述pkc - α的结构特征，深入了解pkc - α在不同细胞区室中的激活机制及其关键生物学功能的调控，从而开发有效的药理学方法来调控pkc - α信号阵列。
Protein kinase C (PKC) comprises a family of lipid-sensitive enzymes that have been involved in a broad range of cellular functions. PKC-alpha is a member of classical PKC with ubiquitous expression and different cellular localization. This unique PKC isoform is activated by various signals which evoke lipid hydrolysis, after activation it interacts with various adapter proteins and is localized to specific cellular compartments where it is devised to work. The universal expression and activation by various stimuli make it a perfect player in uncountable cellular functions including differentiation, proliferation, apoptosis, cellular transformation, motility, adhesion and so on. However, these functions are not intrinsic properties of PKC-alpha, but depend on cell types and conditions. The activities of PKC-alpha are managed by the various pharmacological activators/inhibitors and antisense oligonucleotides. The aim of this review is to elaborate the structural feature, and provide an insight into the mechanism of PKC-alpha activation and regulation of its key biological functions in different cellular compartments to develop an effective pharmacological approach to regulate the PKC-alpha signal array.