Transgenic mice overexpressing macrophage migration inhibitory factor (MIF) exhibit high-turnover osteoporosis
Transgenic mice overexpressing macrophage migration inhibitory factor (MIF) exhibit high-turnover osteoporosis
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DOI：
10.1359/jbmr.060310
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发表时间：
2006-06-01
影响因子：
6.2
通讯作者：
Yasuda, Kazunori
中科院分区：
文献类型：
--
作者：
Onodera, Shin;Sasaki, Satoshi;Yasuda, Kazunori
研究了过表达MIF小鼠的骨表型。这些小鼠表现出骨小梁减少，骨形成率增加，股骨和胫骨中MMP-3， -9和-13 mRNA表达增加。该模型提供了MIF在体内骨重塑和平衡中发挥作用的证据。
The bone phenotype of mice overexpressing MIF was studies. These mice showed decreased trabecular bone, increased bone formation rate, and increased MMP-3, -9, and -13 mRNA expression in the femora and tibias. This model provides evidence of the role played by MIF in bone remodeling and balance in vivo.