Cytotoxic sesquiterpenoids from Senecio densiserratus
Cytotoxic sesquiterpenoids from Senecio densiserratus
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DOI：
10.1016/j.phytol.2016.04.017
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发表时间：
2016-06
影响因子：
1.7
通讯作者：
Mei-li Yang;Jian-Jun Chen;Hong-Bo Wei;K. Gao
中科院分区：
文献类型：
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作者：
Mei-li Yang;Jian-Jun Chen;Hong-Bo Wei;K. Gao
利用细胞毒活性导向的方法，从千里光（SeneciodensiserratusChang）甲醇提取物中分离得到两个新的高氧愈创木烷型倍半萜（1和2），沿着得到9个已知化合物（3-11）。通过波谱分析（IR、HRESIMS、1D和2D NMR）以及与文献数据的比较，确定了它们的结构。这两个新化合物代表了一种罕见类型的愈创木烷倍半萜类葡萄糖苷与当归酰氧基直接连接到糖基部分。化合物1 ~ 3、8和10对人白血病细胞（HL-60）、人肝癌细胞（SMMC-7721）和人宫颈癌细胞（HeLa）具有广谱的体外抑制活性，IC_（50）值在9.5 ~ 28.3 μMin之间。新化合物对植物病原真菌Penicillium italicum和Rhizoctonia solani也表现出中等活性，IC 50值为19.4 - 33.1 μM。
Two new highly oxygenated guaiane-type sesquiterpenoids (1and2), along with nine known compounds (3–11) were isolated from the methanol extract ofSeneciodensiserratusChang by cytotoxicity-guidance. Their structures were elucidated through spectroscopic analysis (IR, HRESIMS, 1D and 2D NMR) as well as by comparison with literature data. The two new compounds represent a rare type of guaiane sesquiterpenoid glucosides with angeloyloxy groups directly connected to the glycosyl moiety. Compounds1–3,8and10displayed broad-spectrum inhibitory activity against the human leukemia cell (HL-60), human hepatoma cell (SMMC-7721) and human cervical carcinoma cell (HeLa), with IC50values ranging from 9.5 to 28.3 μMin vitro. The new compounds also displayed moderate activity against plant pathogenic fungi ofPenicillium italicumandRhizoctonia solaniwith IC50values from 19.4 to 33.1 μM.