Bacterial Flagellins: Does Size Matter?
Bacterial Flagellins: Does Size Matter?
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DOI：
10.1016/j.tim.2017.11.010
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发表时间：
2017-12
影响因子：
15.9
通讯作者：
Nicholas M. Thomson;F. Rossmann;Josie L. Ferreira;Teige R S Matthews-Palmer;M. Beeby;M. Pallen
中科院分区：
文献类型：
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作者：
Nicholas M. Thomson;F. Rossmann;Josie L. Ferreira;Teige R S Matthews-Palmer;M. Beeby;M. Pallen
细菌鞭毛是细菌运动的主要细胞器。在这里，我们解决的问题时，主要鞭毛蛋白鞭毛蛋白和鞭毛细丝的大小。令人惊讶的是，大自然提供了多个“巨型鞭毛蛋白”的例子，其长度超过1000个氨基酸，具有大的表面暴露的超变结构域。我们回顾了这些巨型鞭毛蛋白发生的背景，推测了它们的功能，并强调了生物技术在自然提供的基础上的潜力。
The bacterial flagellum is the principal organelle of motility in bacteria. Here, we address the question of size when applied to the chief flagellar protein flagellin and the flagellar filament. Surprisingly, nature furnishes multiple examples of ‘giant flagellins' greater than a thousand amino acids in length, with large surface-exposed hypervariable domains. We review the contexts in which these giant flagellins occur, speculate as to their functions, and highlight the potential for biotechnology to build on what nature provides.