INDUCTION OF ANTIPHOSPHOLIPID AUTOANTIBODIES BY IMMUNIZATION WITH BETA-2 GLYCOPROTEIN-I (APOLIPOPROTEIN-H)
INDUCTION OF ANTIPHOSPHOLIPID AUTOANTIBODIES BY IMMUNIZATION WITH BETA-2 GLYCOPROTEIN-I (APOLIPOPROTEIN-H)
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DOI：
10.1172/jci115927
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发表时间：
1992-09-01
影响因子：
15.9
通讯作者：
ELKON, KB
中科院分区：
文献类型：
--
作者：
GHARAVI, AE;SAMMARITANO, LR;ELKON, KB
系统性红斑狼疮患者的一个子集具有酸性磷脂的自身抗体。由于脂质是不良的免疫原，导致这些抗体诱导的机制尚不清楚。用纯化的人β-2-糖蛋白I（载脂蛋白H）免疫正常兔和正常小鼠，导致产生高水平的两种非交叉反应性抗体群体，抗载脂蛋白H和抗磷脂。抗磷脂抗体的结合特异性与从人类和小鼠狼疮获得的自身抗体难以区分。这些发现表明了一种新的抗磷脂自身抗体的诱导机制。
A subset of patients with systemic lupus erythematosus has autoantibodies to acidic phospholipids. Since lipids are poor immunogens, the mechanism responsible for the induction of these antibodies is unclear. Immunization of a normal rabbit and normal mice with purified human-beta-2-glycoprotein I (apolipoprotein H) resulted in the production of high levels of two non-cross-reactive antibody populations, anti-apolipoprotein H, and antiphospholipid. The antiphospholipid antibodies had binding specificities indistinguishable from autoantibodies obtained from human and murine lupus. These findings suggest a novel mechanism for the induction of antiphospholipid autoantibodies.