Thickening in the somatosensory cortex of patients with migraine
Thickening in the somatosensory cortex of patients with migraine
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DOI：
10.1212/01.wnl.0000291618.32247.2d
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发表时间：
2007-11-20
期刊：
影响因子：
9.9
通讯作者：
Hadjikhani, Nouchine
中科院分区：
文献类型：
--
作者：
DaSilva, Alexandre F. M.;Granziera, Cristina;Hadjikhani, Nouchine
目的：检查偏头痛患者的躯体感觉皮层（SSC）的形态学变化。方法：偏头痛患者的SSC的皮质厚度在体内进行了测量，并与年龄和性别匹配的健康受试者进行比较。该队列由24名偏头痛患者组成，其中12名患者患有先兆偏头痛，12名患者患有无先兆偏头痛，12名对照。组和个人的分析进行了在SSC和显示为平均地图的显着变化皮质thickness.Results：偏头痛平均厚SSC比对照组。最显着的厚度变化，注意到在尾部SSC，三叉神经区，包括头部和面部，是somatotopically represented.Conclusions：我们的研究结果表明，发作间期的结构变化的存在偏头痛的躯体感觉皮层（SSC）。SSC在伤害性和非伤害性躯体感觉加工中起着至关重要的作用。SSC增厚与先前研究中在同一偏头痛队列的皮层下三叉神经体感通路中观察到的弥散异常一致。反复发作的偏头痛可能导致三叉神经躯体感觉系统的皮质和皮质下结构的神经可塑性变化，或者是三叉神经躯体感觉系统的皮质和皮质下结构的神经可塑性变化的结果。
Objective: To examine morphologic changes in the somatosensory cortex (SSC) of patients with migraine.Methods: Cortical thickness of the SSC of patients with migraine was measured in vivo and compared with age-and sex-matched healthy subjects. The cohort was composed of 24 patients with migraine, subdivided into 12 patients who had migraine with aura, 12 patients who had migraine without aura, and 12 controls. Group and individual analyses were performed in the SSC and shown as average maps of significant changes in cortical thickness.Results: Migraineurs had on average thicker SSCs than the control group. The most significant thickness changes were noticed in the caudal SSC, where the trigeminal area, including head and face, is somatotopically represented.Conclusions: Our findings indicate the presence of interictal structural changes in the somatosensory cortex (SSC) of migraineurs. The SSC plays a crucial role in the noxious and nonnoxious somatosensory processing. Thickening in the SSC is in line with diffusional abnormalities observed in the subcortical trigeminal somatosensory pathway of the same migraine cohort in a previous study. Repetitive migraine attacks may lead to, or be the result of, neuroplastic changes in cortical and subcortical structures of the trigeminal somatosensory system.