Induction of a nonproductive conformational change in gp120 by a small molecule HIV type 1 entry inhibitor
Induction of a nonproductive conformational change in gp120 by a small molecule HIV type 1 entry inhibitor
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DOI：
10.1089/aid.2006.0137
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发表时间：
2007-01-01
影响因子：
1.5
通讯作者：
Chen, Chin Ho
中科院分区：
文献类型：
--
作者：
Huang, Li;Lai, Weihong;Chen, Chin Ho
Conformational changes in HIV-1 envelope glycoproteins, gp120 and gp41, is a dynamic process essential for HIV-1 entry. Here we show that a small molecule HIV-1 entry inhibitor, IC9564, induces a conformational change in gp120. The conformational change in gp120 is evidenced by a significant increase in the binding of a conformational monoclonal antibody 17b. As a result of the conformational effect, IC9564 significantly enhances the neutralizing activity of 17b. Unlike CD4, IC9564 does not trigger conformational changes in gp41. In fact, IC9564 inhibits CD4-induced conformational changes in gp41. Thus, IC9564 exploits the dynamic nature of gp120 by inducing a nonproductive gp120 conformation that is not able to trigger a conformational change in gp41 for membrane fusion.
